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- W2185068835 abstract "OBJECTIVE: The aim of this study was to investigate the effect of Magne- sium Isoglycyrrhizinate (MgIG) on intercellular adhesion moledule-1 (ICAM-1) and matrix met- alloproteinase-9 (MMP-9) in rats with Paraquat (PQ) poisoning and its potential mechanism. MATERIALS AND METHODS: 30 male Sprague Dawley rats were randomly divided into five groups, including normal control group, poi- soned control group, low-dose MgIG group, medium-dose MgIG group and high-dose MgIG group. Each group was treated with correspond- ing dose of MgIG once on daily basis by in- traperitoneal injection 24 hours later, and the normal control group and poisoned control group were injected with physiological saline. All the animals were killed 14 days after poison- ing, the contents of ICAM-1 and matrix MMP-9 were determined. HE staining and Masson stain- ing were performed, the hydroxyproline (HYP) content in the lung tissue was also determined, and the expressions of ICAM-1 and MMP-9 were detected by immunohistochemical test. RESULTS: The contents of ICAM-1 and MMP-9 in the rat serum for all treatment groups were significantly decreased compared with those of the poisoned control group (p < 0.05, or < 0.01), and the expressions of the two proteins were significantly down-regulated, especially for the medium dose group. CONCLUSIONS: There is an improvement ef- fect of ICAM-1 and MMP-9 in rats with Paraquat poisoning for the medium dose of MgIG, capa- ble of slowing down the process of pulmonary fibrosis to certain extent." @default.
- W2185068835 created "2016-06-24" @default.
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- W2185068835 date "2014-01-01" @default.
- W2185068835 modified "2023-09-27" @default.
- W2185068835 title "Therapeuticeffectofmagnesiumisoglycyrrhizinate inratsonlunginjuryinducedbyparaquatpoisoning European Review for Medical and Pharmacological Sciences" @default.
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