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- W2185094278 abstract "SUMMARY A double-blind trial ofa protein-free liver extract (Ripason) whichwas administered bothorally andintramuscularly isdescribed in20patients withstable cirrhosis. Controland treated groupsweresimilar incomposition except forage.Bothgroupsshowedsome symptomatic improvement during thetrial. Fewerpatients wererecorded asworseon Ripason butno significant changes inbodyweight, haemoglobin, orliver function tests couldbedetected. Purified liver extracts havebeenusedforanumber ofyears inthetreatment ofbothacute andchronic liver disease. Ripason, aprotein-free liver extract, wasintroduced in1953andhasbeenshowntohave beneficial effects inbothexperimental andclinical studies. Burri (1953) andHartmann (1953) showed ittohavealipotropic effect inthecarbon tetrachloride damaged ratliver andRoulet (1958), also using rats, demonstrated aprotective effect ofthis extract intheinduction ofcirrhosis bycholine deficiency. Inrabbits itmaystimulate regeneration ofliver parenchyma afterpartial hepatectomy (Grifoni andRucci, 1962). A large numberofclinical reports ontheuseof oralandparenteral preparations ofRipason have indicated itsvalueinvarious types ofacuteand chronic hepatic disease (Paraf, 1954; Stiefel and Jasinski, 1963;Gutewa, 1962;Dioguardi, 1956). However, allthese trials havebeenuncontrolled andofteninvolved onlysubjective assessment of thepatients' improvement. Inthis paper wepresent theresults ofa double-blind controlled trial of Ripason therapy inchronic liver disease." @default.
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- W2185094278 date "1969-01-01" @default.
- W2185094278 modified "2023-09-27" @default.
- W2185094278 title "A controlled trial ofaprotein-free liver extract inthetreatment ofchronic liver disease" @default.
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