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• W2185099881 abstract "Hepatic lipase (HL) is a secretory protein synthesized in hepatocytes and bound to liver endothelium. Previous studies have suggested that HL N-linked glycans are required for catalytic activity. To directly test this hypothesis, Xenopus laevis oocytes were used to express native rat HL or HL lacking one or both N-linked glycosylation sites. The expressed and secreted native HL had an apparent molecular mass of 53 kDa, consistent with purified rat liver HL. The mutant lacking both glycosylation sites, while poorly secreted, had an apparent molecular mass of 48 kDa, the same size observed for HL after enzymatic removal of N-linked oligosaccharides. Mutants lacking one of the two sites were intermediate in size and showed reduced secretion. Each of these expressed and secreted proteins had full catalytic activity that was inhibited by antisera to rat HL. Thus, N-linked glycosylation of rat HL, while important to lipase secretion, is not essential for the expression of lipase activity." @default.
• W2185099881 created "2016-06-24" @default.
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• W2185099881 date "1991-03-01" @default.
• W2185099881 modified "2023-09-23" @default.
• W2185099881 title "Effect of N-linked glycosylation on hepatic lipase activity" @default.
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• W2185099881 doi "https://doi.org/10.1016/s0022-2275(20)42071-1" @default.
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