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- W2185108668 abstract "Figure 1. Status of GHS Implementation The rapidly changing global landscape of environmental regulations and chemical compliance presents a major challenge for chemical manufacturers and importers. Increasingly, countries are requiring hazard identification based on the Globally Harmonized System of Classification and Labeling (GHS) Guidance. The use of a GHS-based classification system is complex and calls for a level of expertise in toxicology and chemistry that was not previously needed to communicate chemical safety. As part of the hazard assessment process, we identified a recurring complication regarding hazard assignment for substances that have variable compositional features but share the same Chemical Abstracts Service (CAS) Registry Number. CAS numbers are unique chemical-specific identifiers; however, they are not specific to length, size, and composition. Examples of such compounds include silica, petroleum distillates, alcohol ethoxylates, and glass oxide. We determined that hazard conclusions can vary considerably across the publicly available literature for a specific CAS number, and information on the chemical manufacturing process is often necessary to appropriately assign hazards. For example, based on the CAS number alone, an evaluation of glass oxide (CAS No. 65997-17-3) would suggest a potential carcinogenic risk because this CAS number is classified as a class 1B carcinogen in the associated Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) registration dossier (without any caveats). Such a classification would potentially trigger significant downstream regulatory requirements. Based on a targeted investigation into product specifications on particle size, however, we determined that the glass oxide in question consisted of continuous filament glass fibers with aerodynamic diameters ranging from 8-26 µm, which are unlikely to deposit in the alveoli regions of the lungs and thus unlikely to pose carcinogenic risks. This poster presents examples of the complexities associated with assessing hazards for several compounds with variable compositional features and describes a strategy for arriving at well-supported hazard conclusions." @default.
- W2185108668 created "2016-06-24" @default.
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- W2185108668 date "2015-01-01" @default.
- W2185108668 modified "2023-09-26" @default.
- W2185108668 title "GHS Hazard Assessment of CAS Number-Specific Compounds with Variable Composition - A Comprehensive Approach" @default.
- W2185108668 hasPublicationYear "2015" @default.
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