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- W2185113252 abstract "This study is investigation of tableting compression behaviour of protein pharmaceutical in tablet formulations by the use of trypsin–chymotrypsin s as model drug. The trypsin‐chymotrypsin mixture (in the activity ratio 6:1) having enzymatic activity of 2000 AU/mg. 50% Trypsin‐chymotrypsin, 26 % microcrystalline cellulose , 7.5% Sodium Bicarbonate‐Citric acid mixture(in ratio70:30),6.5% lactose or Starch, 5.5%Magnesium stearate were dry mixed.dry mixed blend is subjected to binding by using 4.5% Polyvinyl Pyrrolidone solution in Isopropanol.then granulated using Mesh No. 14 after dehumidification at 50 0 C under vacuum. A 100‐mg sample was compressed by using deep biconcave 9‐mm punches and dies at the compression force of 70, 80, 90, and100 KN (Kilo Newton) at a speed of 25 mm/min. the tablet compression was performed with granules containing 6.5% lactose (without starch), in contrast, tablets were formulated by using granules contains 6.5% starch (without lactose ) to investigate effect of excipients on compression behaviour of enzyme mixture. Then the tablets were coated with 12.50% w/w solution of ethyl cellulose in dichloromethane and diethyl phthalate as plasticizer. Ethyl cellulose as a coating material can prevent the influx of the dissolution medium into the tablet core, and thus decrease the premature dissolution and release of the drug from the enteric‐coated tablet at acidic pH. The hardness of tablets formulated with higher compression force significantly higher than those formulated with lower compression force. Drug dissolution profile shows significant decrease in the drug release due to denaturation from activity loss under high compression force so tablets prepared at 70 KN Compression force shows higher activity. The compression behaviour of tablet with different excipient can be study using a dissolution study. As increases pressure decreases enzymatic activity. The enzymatic activity in tablets prepared using starch at 70 KN was significantly higher than that prepared using lactose at same compression force because starch shows elastic deformation at low pressure and plastic deformation at high pressure" @default.
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- W2185113252 date "2009-01-01" @default.
- W2185113252 modified "2023-09-27" @default.
- W2185113252 title "TABLETING COMPRESSION BEHAVIOUR OF ENZYME TRYPSINCHYMOTRYPSIN" @default.
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