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- W2185136125 abstract "Sparfloxacin is a third generation fluroquinolone derivative used as antimicrobial agent in human as well as in livestock. To establish proper dosage regimen in healthy as well as in acute renal failure condition in goat sparfloxacin was administered at a dose rate of 30 mg kg -1 body weight by intravenous route. Kidney was damaged experimentally by blocking urinary bladder and was assured by increased blood urea nitrogen and plasma creatinine level. The values of Cpmax and Cpmin of sparfloxacin in healthy goats were found to be 18.36 ± 0.52 and 0.66 ± 0.01 µg ml -1 at 0.08 and 10 hr respectively, while the respective values were 21.16 ± 0.44 and 0.53 ± 0.03 µg ml -1 at 0.08 and 14 hr in goats of acute renal failure. Pharmacokinetic parameters like B, t ½ β, AUC and MRT were higher in acute renal failure goats where as β and ClB values were decreased compared to healthy goats. Acute renal failure condition alters kinetic behavior of sparfloxacin in goats." @default.
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- W2185136125 date "2010-01-01" @default.
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- W2185136125 title "Effect of Acute Renal Failure on the Disposition Kinetics of Sparfloxacin in Goats" @default.
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