Matches in SemOpenAlex for { <https://semopenalex.org/work/W2185145162> ?p ?o ?g. }
- W2185145162 endingPage "342" @default.
- W2185145162 startingPage "329" @default.
- W2185145162 abstract "A series of phosphodiester and phosphorothioate antisense oligodeoxynucleotides were synthesized against the human transferrin receptor (TfR). The phosphorothioate analogs exhibited marked biologic efficacy in culture, as assessed by inhibition of surface TfR content and HL-60 cell growth, whereas their unmodified phosphodiester counterparts were ineffective. Phosphorothioate oligodeoxynucleotides were more resistant to hydrolysis by serum and cellular nucleases and were more readily taken up by cells than phosphodiesters, thus providing a partial explanation for the differences in biologic activity. A length effect was observed, with antisense 30-mers exhibiting greater TfR inhibitory activity than 17-mers. The degree of receptor inhibition observed, however, was not sequence dependent, suggesting that the phosphorothioate oligodeoxynucleotides may have pleiotropic activities in eukaryotic cells in addition to inhibiting gene expression by classic antisense complementary binding to mRNA." @default.
- W2185145162 created "2016-06-24" @default.
- W2185145162 creator A5010978242 @default.
- W2185145162 creator A5018474662 @default.
- W2185145162 creator A5043512123 @default.
- W2185145162 creator A5086652615 @default.
- W2185145162 date "1991-01-01" @default.
- W2185145162 modified "2023-10-14" @default.
- W2185145162 title "Non–Sequence-Specific Inhibition of Transferrin Receptor Expression in HL-60 Leukemia Cells by Phosphorothioate Oligodeoxynucleotides" @default.
- W2185145162 cites W1487851602 @default.
- W2185145162 cites W1491697220 @default.
- W2185145162 cites W1498549327 @default.
- W2185145162 cites W1547570172 @default.
- W2185145162 cites W1915302814 @default.
- W2185145162 cites W1963871104 @default.
- W2185145162 cites W1966942560 @default.
- W2185145162 cites W1971597849 @default.
- W2185145162 cites W1972711906 @default.
- W2185145162 cites W1982129404 @default.
- W2185145162 cites W1983940060 @default.
- W2185145162 cites W1985791255 @default.
- W2185145162 cites W1990548509 @default.
- W2185145162 cites W1994204471 @default.
- W2185145162 cites W1995129870 @default.
- W2185145162 cites W2000759543 @default.
- W2185145162 cites W2002645111 @default.
- W2185145162 cites W2003868867 @default.
- W2185145162 cites W2019757220 @default.
- W2185145162 cites W2020678086 @default.
- W2185145162 cites W2021183494 @default.
- W2185145162 cites W2022013776 @default.
- W2185145162 cites W2035152288 @default.
- W2185145162 cites W2036607840 @default.
- W2185145162 cites W2044443446 @default.
- W2185145162 cites W2056627100 @default.
- W2185145162 cites W2058743880 @default.
- W2185145162 cites W2060546037 @default.
- W2185145162 cites W2066050654 @default.
- W2185145162 cites W2068230814 @default.
- W2185145162 cites W2072246224 @default.
- W2185145162 cites W2073115409 @default.
- W2185145162 cites W2079242913 @default.
- W2185145162 cites W2081271027 @default.
- W2185145162 cites W2083862437 @default.
- W2185145162 cites W2093514167 @default.
- W2185145162 cites W2109790916 @default.
- W2185145162 cites W2148320915 @default.
- W2185145162 cites W4256412995 @default.
- W2185145162 doi "https://doi.org/10.1089/ard.1991.1.329" @default.
- W2185145162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1821654" @default.
- W2185145162 hasPublicationYear "1991" @default.
- W2185145162 type Work @default.
- W2185145162 sameAs 2185145162 @default.
- W2185145162 citedByCount "39" @default.
- W2185145162 countsByYear W21851451622013 @default.
- W2185145162 countsByYear W21851451622015 @default.
- W2185145162 crossrefType "journal-article" @default.
- W2185145162 hasAuthorship W2185145162A5010978242 @default.
- W2185145162 hasAuthorship W2185145162A5018474662 @default.
- W2185145162 hasAuthorship W2185145162A5043512123 @default.
- W2185145162 hasAuthorship W2185145162A5086652615 @default.
- W2185145162 hasConcept C104317684 @default.
- W2185145162 hasConcept C105580179 @default.
- W2185145162 hasConcept C129312508 @default.
- W2185145162 hasConcept C153911025 @default.
- W2185145162 hasConcept C170493617 @default.
- W2185145162 hasConcept C185592680 @default.
- W2185145162 hasConcept C22814914 @default.
- W2185145162 hasConcept C32264632 @default.
- W2185145162 hasConcept C38441620 @default.
- W2185145162 hasConcept C54355233 @default.
- W2185145162 hasConcept C55493867 @default.
- W2185145162 hasConcept C62112901 @default.
- W2185145162 hasConcept C67705224 @default.
- W2185145162 hasConcept C81885089 @default.
- W2185145162 hasConcept C86803240 @default.
- W2185145162 hasConceptScore W2185145162C104317684 @default.
- W2185145162 hasConceptScore W2185145162C105580179 @default.
- W2185145162 hasConceptScore W2185145162C129312508 @default.
- W2185145162 hasConceptScore W2185145162C153911025 @default.
- W2185145162 hasConceptScore W2185145162C170493617 @default.
- W2185145162 hasConceptScore W2185145162C185592680 @default.
- W2185145162 hasConceptScore W2185145162C22814914 @default.
- W2185145162 hasConceptScore W2185145162C32264632 @default.
- W2185145162 hasConceptScore W2185145162C38441620 @default.
- W2185145162 hasConceptScore W2185145162C54355233 @default.
- W2185145162 hasConceptScore W2185145162C55493867 @default.
- W2185145162 hasConceptScore W2185145162C62112901 @default.
- W2185145162 hasConceptScore W2185145162C67705224 @default.
- W2185145162 hasConceptScore W2185145162C81885089 @default.
- W2185145162 hasConceptScore W2185145162C86803240 @default.
- W2185145162 hasIssue "4" @default.
- W2185145162 hasLocation W21851451621 @default.
- W2185145162 hasLocation W21851451622 @default.
- W2185145162 hasOpenAccess W2185145162 @default.
- W2185145162 hasPrimaryLocation W21851451621 @default.
- W2185145162 hasRelatedWork W1797708587 @default.
- W2185145162 hasRelatedWork W1985279299 @default.