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- W2185149780 abstract "Gedunin, a highly oxidized triterpenoid was obtained from hexane extractive of stem wood of Entandrophragma angolense (Welw) C. D. C. of the family Meliaceae . The gedunin was dissolved in minimum methanol at 40°C and set aside in the dark for recrystallization. Pure gedunin crystals were obtained in 0.92% yield. Methanolic alkaline hydrolysis of the gedunin afforded 7-deacetoxy-7αhydroxygedunin potassium salt in 90.53% w/w yield. The gedunin and 7-deacetoxy-7α-hydroxygedunin potassium salt were screened against Bacillus subtilis , Staphylococcus aureus , Escherichia coli , and Klebsiella pneumoniae using broth microdilution assay method. 7-Deacetoxy-7α-hydroxygedunin potassium salt had minimum inhibitory concentration (MIC) of 1000 �g/ml against K. pneumoniae, 2000 �g/ml against S. aureus , and E. coli . However, B. subtilis was not susceptible to 7-deacetoxy-7αhydroxygedunin potassium salt at 2000 �g/ml. Gedunin was not active against all the bacterial organisms tested at 2000 �g/ml." @default.
- W2185149780 created "2016-06-24" @default.
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- W2185149780 date "2012-01-01" @default.
- W2185149780 modified "2023-09-26" @default.
- W2185149780 title "Synthetic modification of gedunin and comparative antibacterial activity of gedunin and 7-deacetoxy-7α- hydroxygedunin potassium salt" @default.
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