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- W2185200034 abstract "polyphosphoinositides were found to correlate closely with steroidogenesis in a variety of circumstances, and cycloheximide concomitantly blocked the stimulatory effects of ACTH and cAMP on polyphosphoinositides and steroidogenesis. It was thus suggested that polyphosphoinositides may function as a mediator in the steroidogenic actions of ACTH and CAMP. The mechanism whereby ACTH increases polyphosphoinositides is presently unclear. Phosphatidylinositol, the immediate precursor for the polyphosphoinositides, is reportedly increased by ACTH treatment of cat adrenal cells in vitro (3, and it is possible that this may underlie the increase in polyphosphoinositides. Alternatively, an increase in phosphatidylinositol kinase activity or a decrease in polyphosphoinositide breakdown might also be responsible for the ACTHinduced increase in pol-yphosphoinositides. In the present studies, we evaluated these possibilities. Our results suggest that the ACTH-induced increase in polyphosphoinositides is due to a rapid increase in phosphatidic acid and, subsequently, CDP-diacylglycerol and phosphatidylinositol. EXPERIMENTAL PROCEDURES" @default.
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- W2185200034 date "1980-01-01" @default.
- W2185200034 modified "2023-09-27" @default.
- W2185200034 title "On the Mechanism whereby ACTH and Cyclic AMP Increase Adrenal Polyphosphoinositides" @default.
- W2185200034 hasPublicationYear "1980" @default.
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