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• W2185202173 abstract "OuraimwastousePET/MRItoevaluateandcomparetheuptake of 18 F-FDG, 3-deoxy-3- 18 F-fluorothymidine ( 18 F-FLT), and 18 Ffluorethylcholine ( 18 F-FEC) in human pancreatic tumor cell lines after xenotransplantation into SCID mice and to correlate tumor uptake with gene expression of membrane transporters and rate-limiting enzymes for tracer uptake and tracer retention. Methods:Fourweeksafterorthotopicinoculationofhumanpancreatic carcinoma cells (PancTuI, Colo357, and BxPC3) into SCID mice, combined imaging was performed with a smallanimal PET scanner and a 3-T MRI scanner using a dedicated mouse coil. Tumor-to-liver uptake ratios (TLRs) of the tracers were compared with gene expression profiles of the tumor cell linesandbothnormalpancreatictissueandpancreatictumortissue based on gene microarray analysis and quantitative polymerase chain reaction. Results: 18 F-FLT showed the highest tumor uptake, with a mean TLR of 2.3, allowing correct visualization of all 12 pancreatic tumors. 18F-FDG detected only 4 of 8 tumors and had low uptake in tumors, with a mean TLR of 1.1 in visible tumors. 18F-FEC didnot show anytumor uptake. Gene array analysis revealed that both hexokinase 1 as the rate-limiting enzyme for 18F-FDG trapping and pancreas-specific glucose transporter 2 were significantly downregulated whereas thymidine kinase 1, responsible for 18 F-FLT trapping, was significantly upregulated in the tumor cell lines, compared with normal pancreatic duct cells and pancreatic tumor tissue. Relevant genes involvedintheuptakeof 18 F-FECwerepredominantlyunaffected ordownregulated in thetumorcell lines.Conclusion:In comparison to 18F-FDG and 18F-FEC, 18F-FLT was the PET tracer with the highest and most consistent uptake in various human pancreatic tumor cell lines in SCID mice. The imaging results could be explained by gene expression patterns of membrane transporters and enzymes for tracer uptake and retention as measured by gene array analysis and quantitative polymerase chain reaction in the respective cell lines. Thus, standard moleculartechniquesprovidedthebasistohelpexplainmodel-specific tracer uptake patterns in xenotransplanted human tumor cell lines in mice as observed by PET." @default.
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• W2185202173 date "2008-01-01" @default.
• W2185202173 modified "2023-09-27" @default.
• W2185202173 title "Orthotopic Mouse Xenotransplantation Model of Pancreatic Cancer" @default.
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