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• W2185204115 abstract "The development of metal-based antitumor drugs has been stimulated by the clinical success of cisplatin and its analogs and by the clinical trials of other platinum and ruthenium complexes with activity against resistant tumors and with reduced toxicity of normal cells. In the present study, the newly synthesized (OsII(bpy)2(acac))(PF6) and (RuII(bpy)2(acac))(PF6) complexes were tested for their cytotoxicities against Eherlich Ascites Cells (EAC) carcinoma, for their superoxide dismutase (SOD)- like activities and for their cytoprotective effects of the normal human red blood cells (RBCs) against photo-irradiation induced by UV-lamb in the presence of m-chloroperbenzoic acid, in vitro. Also, their killing capabilities for the growth of EAC carcinoma in vivo and the measurements of the biochemical changes accompanying such killing were investigated. The in vitro study revealed that the average cytoprotective effects of RBCs, SOD- like activities and the cytotoxicity of EAC by similar concentrations of rutheniumII (RuII) and osmium (OsII) complexes were 91.5%, 89.5% and 90% and 98.3%, 89.8% and 92.8%, respectively. In the in vivo study, the mean SOD activities in both RBCs and liver of the tumorized mice were statistically significantly inhibited compared with those of the control group (P 0.05, respectively). Also, the mean activity of catalase was inhibited in liver tissues in the tumorized animals and re-elevated after complexes treatment. In addition, treatment with these complexes elevate the glutathione (GSH) levels in liver tissues of the tumorized and normal mice with simultaneous reduction in the mean levels of the corresponding values of malondialdehyde. On the other side, the mean levels of triglycerides and cholesterol were reduced in serum but the mean levels of total lipids and total proteins were elevated in liver tissues after treatment. Moreover, the mean levels of DNA and RNA were significantly elevated in liver tissues of the tumorized animals and significantly reduced after treatment of the tumorized mice with the complexes. The previous results reflect tumor growth inhibition and prevention of EAC carcinoma metastasis into the liver. In conclusion, RuII and OsII bipyridine complexes are promising free radical scavengers in phototherapy and may be used as anti-tumor and anti-metastatic agents in the clinical trials in the future. (El-Shahat A. Toson. Chemistry Department (Biochemistry Division), Faculty of Science (Damietta), Mansoura University, Egypt. Cancer Biology 2011;1(2):17-28). (ISSN: 2150-1041). http://www.cancerbio.net." @default.
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• W2185204115 date "2011-01-01" @default.
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• W2185204115 title "Antitumor effects of osmium (II) and ruthenium (II) bipyridine complexes containing the acetylacetonato ligand against the growth of Eherlich Ascites Cell Carcinoma" @default.
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