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• W2185282913 abstract "Overpopulation is a burning problem for developing countries like India. Several contraceptive measures have been adopted to control fertility but nowadays scientists are looking for herbal contraceptives which are cheaper and less or nontoxic. Jussiaea repens (L), a well known Indian medicinal plant, reported as nontoxic anti gonadal herb on male rats when administered orally. The present study was undertaken to investigate the probable mode of action of this plant (except root) as anti fertile agent and to study the reversible effect in rats, so that it can be used as alternative safe male herbal contraceptive in future. The aqueous extract at a dose of 200 mg/kg b.wt./day orally for 28 days has potent anti fertility activity that may be due to decreased testicular ascorbic acid, glycogen, Δ5-3β and 17β HSD, G-6PDH, ATPase, LDH activities and increased level of cholesterol, which are directly related to testicular functions. The testicular protein content was unaltered but Zn content was reduced insignificantly than control. Serum triglycerides, VLDL, LDH and G-6PDH were significantly reduced in treated group keeping HDL unaltered but Zn content was reduced insignificantly where the significant rise of cholesterol and LDL level were noticed. A significant decrease of protein content, Zn, ATPase and LDH activities in epididymis were also observed after treatment, which supported the anti gonadal activity. Altered biochemical parameters may affect the maturation process of spermatogenesis which was reflected through increased percentage of denatured chromatin in spermatozoa. Restoration of all the biochemical parameters in the recovery group also supported the reversal effect of the extract after withdrawal of treatment. So, from the above studies it can be assumed that crude aqueous extract of J. repens at a regulated dose and duration, may be used as male herbal contraceptive without causing any permanent damage of the reproductive system or side effects in general." @default.
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• W2185282913 date "2014-01-01" @default.
• W2185282913 modified "2023-09-23" @default.
• W2185282913 title "Jussiaea repens (L) Acts as an Antifertility Agent - A Search for Herbal Male Contraceptive" @default.
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