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- W2185323015 abstract "Gonorrhea is one of the most common sexually transmitted diseases all over the world caused by Neisseria gonorrhoeae. Till date only antibiotic treatment is recommended and no specific drug is available. The number of drug resistant stains is also increasing. In this study, using in silico subtractive genomics approach, membrane associated candidate drug targets have been identified in N. gonorrhoeae virulent strain FA 1090. The analysis revealed that out of 2002 protein coding sequences of the gonococcus, 217 essential genes are non-human homologs (putative drug targets) and subsequent analysis of these protein products has identified 63 membrane associated drug targets of which 13 are possibly surface proteins. Out of these 13 surface proteins, four proteins were identified, two from host-pathogen common and two from pathogen specific unique metabolic pathways. These four targets require further investigation." @default.
- W2185323015 created "2016-06-24" @default.
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- W2185323015 date "2009-01-01" @default.
- W2185323015 modified "2023-09-29" @default.
- W2185323015 title "In silico identification of membrane associated candidate drug targets in Neisseria gonorrhoeae" @default.
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