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• W2185331315 abstract "Objectives. Leptin is an adipocyte-secreting hormone that regulates appetite and body weight. In non-diabetic subjects, its concentration correlates with insulin resistance. However, in type 2 diabetic patients, this relationship is inconsistent. Because of the differences in leptin concentration across ethnicities, compared with healthy subjects, in type 2 diabetic patients and the ethnic differences related to insulin resistance, the purpose of this study was to investigate the relationship between leptin concentration and insulin resistance in Chinese type 2 diabetic patients. Methods. We recruited 172 type 2 diabetic patients C75 men and 97 women) into this study. Fasting plasma glucose, serum insulin, leptin concentration, and body mass index (BMI) were measured. Homeostasis model assessment (HOMA) was used to estimate insulin resistance. Results. Simple linear regression analysis revealed that HOMA and BMI independently correlated with leptin concentration (p ＜ 0.00l) in both genders. Multiple linear regression analysis showed that in male subjects (n = 75) and female subjects (n = 97), HOMA and BMI were each significant predictors of leptin concentration, and that these factors accounted for 45.45% of the variance in leptin concentration (R2 = 0.4545) in male subjects and 37.34% of the variance (R2= 0.3734) in female subjects. Even after further adjusting for insulin resistance and hypertension, and modifying the medication, HOMA and BMI were still shown to be independently correlated with leptin concentration in both genders.Conclusions. Leptin concentration significantly correlated with insulin resistance in Chinese type 2 diabetic patients. This relationship was not gender specific." @default.
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• W2185331315 date "2003-09-01" @default.
• W2185331315 modified "2023-09-23" @default.
• W2185331315 title "The Relationship Between Leptin Concentration and Insulin Resistance in Chinese Type 2 Diabetic Patients" @default.
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• W2185331315 doi "https://doi.org/10.6558/mtjm.2003.8(3).4" @default.
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