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• W2185336968 abstract "In the past, hormonal therapy was only used for the treatment of metastatic prostatic cancer, but it has now assumed an increasingly important role in the management of intermediate and high risk localized prostate cancer as neoadjuvant or adjuvant treatment. It also has a role in treatment of local or distant failure after radiation. This review summarises the recent developments and the issues to be explored in the future: from chemoprevention to treatment. 5-alpha-reductase inhibition using drugs such as finasteride have been shown to decrease androgenic stimulation of the prostate and currently being tested in chemoprevention trials. Bilateral orchiectomy has been regarded as the gold standard of therapy, to which other treatments are compared. Most published studies showed no extra benefit of total androgen blockade (TAB) over monotherapy. TAB results in more hot flushes, fatigue, bone and joint pain, osteoporosis and fracture, anaemia, impotence. Anti-androgens do not seem to affect sexual function, physical capacity, strength and vitality as much. However gynaecomastia is more common with monotherapy antiandrogen than TAB. When hormone is combined with radiotherapy in both RTOG 85-31 and RTOG 86-10 studies, statistically significant improvements in outcome were observed between the radiotherapy and hormones combined (group I) and radiotherapy alone (group II) groups, when analysed for biochemical disease-free survival and distant metastases failure. Currently another ongoing research area is the intermittent androgen deprivation approach, which is meant to provide treatment to control the tumour, with a potential for prolonged therapy-free intervals resulting in improved quality of life, delay in progression to androgen independence, and reduced cost of therapy. Terapia hormonalna w miejscowo zaawansowanym raku prostaty – aspekty praktyczne" @default.
• W2185336968 created "2016-06-24" @default.
• W2185336968 creator A5035492241 @default.
• W2185336968 date "2003-01-01" @default.
• W2185336968 modified "2023-09-26" @default.
• W2185336968 title "Practical aspects of hormonal therapy for localized prostate cancer" @default.
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