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- W2185338082 abstract "Background : The occurrence of drug multi–resistant Mycobacterium tuberculosis among the HIV seropositive patients has raised global public health concern. This study was, therefore, undertaken to determine the prevalence of multi-drug resistant tuberculosis( MDR-TB) among HIV seropositive and seronegative patients in Abeokuta, Nigeria. Methods: A total of five hundred and four (504) sputum samples from deep coughs were collected from TB suspects who came to register for the first time at public health facilities in Abeokuta, Nigeria. Sputum samples were decontaminated using N-acetyl-L-cysteine-sodium hydroxide (NALC-NaOH) and cultured on Lowenstein Jensen (L J) medium. Each isolate was culturally and biochemically characterized by standard methods and their drug susceptibility tests (DST) to first line anti-tuberculosis drugs (isoniazid, rifampicin, streptomycin and ethambutol) were performed by proportion method. Patients were screened for HIV infection by using Determine, Unigold and Stat-pak HIV test kits and confirmed by Western blot technique. Socio-demographic data of the patients were obtained by administering questionnaires and conducting personal interviews. Results: Out of 504 patients, 7.9% prevalence of HIV infection was recorded. Of 289 males, 11.4% was seropositive while 7.9% of the 215 females were seropositive. The occurrence(62.5%) of TB in HIV patients was found to be associated with HIV (P<0.05). The overall prevalence of multi-drug resistant Mycobacterium tuberculosis among TB patients was found to be 5.8%. MDR-TB was found to be" @default.
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- W2185338082 date "2013-01-01" @default.
- W2185338082 modified "2023-09-27" @default.
- W2185338082 title "PRIMARY MULTI-DRUG RESISTANT TUBERCULOSIS AMONG HIV SEROPOSITIVE AND SERONEGATIVE PATIENTS IN ABEOKUTA, SOUTHWESTERN NIGERIA" @default.
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