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- W2185364698 abstract "BACKGROUND: Reperfusion thera - py used in the treatment of cerebral ischemia often causes reperfusion neurological injury. Multiple pathological processes are involved in this injury including oxidative stress and components of the inflammatory response appear to play key roles in these deleterious effects. Thus new therapeutic strategies aimed at neutralization of OS-induced neurotoxicity support the application of natural antioxidant bioflavonoids. Both experimental and epidemiological evidence demonstrate that bioflavonoid such as quercetin and rutin are neuro - protective in models of cerebral ischemia reperfu - sion injury. However, recent studies indicate that the radical scavenger property of quercetin and rutin is unlikely to be the only reason for their cere - broprotective actions and in fact, a wide spectrum of cellular signaling events may well account for their biological actions. AIM: In this study we attempted to establish the various mechanisms involved in the cerebro - protective activity of quercetin and rutin. METHODS: Adult Sprague Dawely rats were anesthetized with thiopentone and subjected to global cerebral ischemia by occlusion of bicom - mon carotid arteries. Infarct size (TTC staining), SOD, MDA, CAT and MPO levels was assessed 4 h after the onset of ischemia. RESULTS: Quercetin (50 mg/kg) and rutin (10 mg/kg) administered 10 min before reperfusion resulted in significant reduction of infarct size, MDA, and MPO levels and significant increase in SOD and CAT levels. Administration of L-NAME prior to administration of quercetin and rutin, significantly reduced the cerebroprotection of - fered by quercetin and rutin. CONCLUSIONS: Possible partial role of an - tioxidant, anti-inflammatory and involvement of NO in the beneficial effects of bioflavonoids quercetin and rutin against cerebral ischemia reperfusion injury was observed." @default.
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- W2185364698 date "2013-01-01" @default.
- W2185364698 modified "2023-09-27" @default.
- W2185364698 title "Partialroleofmultiplepathwaysininfarctsize limitingeffectofquercetinandrutinagainst cerebralischemia-reperfusioninjuryinrats" @default.
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