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• W2185366901 abstract "Maija-Riitta Hirvonen, professor1,2 1 National Public Health Institute, Department of Environmental Health (KTL) FINP.O.Box 95, 70701Kuopio, Finland 2 Faculty of Natural and Environmental Sciences, University of Kuopio FIN-P.O.Box 1627, 70211 Kuopio, Finland Background The behaviour of indoor air bioaerosols has been a focus of interest all over the word due to health concerns associated with exposure to moisture damaged buildings. Special interest is the new buildings constructed with plaster on mineral wool or cellular plastics in the outer walls, also containing gypsum board. In the present case, a large proportion of buildings moisture damages have been found with growth of toxin producing species. Thus, there is a need to evaluate the health risks from living in buildings with these moisture/mould damages in the outer walls before restoring activities can be initiated. The main purpose was to find out the scientific needs for research needed for an acceptable risk evaluation of a 200 single- family houses which is made available to follow during the restoring period of 2.5 years. Suggestions for toxicological characterization of inhaled exposure For risk evaluation toxicological data is needed 1) to provide information on toxic potential of emissions (dose-dependency) 2) to show biological plausibility for the epidemiological findings suggesting that exposure to inhalable agents in moisture damaged buildings impairs human health and 3) to determine relationships between chemical, microbiological and toxicological characteristics of the exposure. Thus, it would be important to make toxicological /microbiological /chemical (e.g.toxin) measurements of the same sample before and after remediation. Combining these data would provide important new information of causative agents/components in the complex mixture of inhaleable particles inluding microbial species, their spores, toxins and other metabolites together with other chemical compounds. Moreover, this would facilitate the development of a new sampling approach and enable modeling to estimate exposure indoors and related health impacts. It is notable that sample collection for the toxicological analysis is chrusal, since building materials as such or other contaminants may cause toxic responses in the test cells. Therefore, settle dust samples, which can be collected also from large number of houses, or air samples (limited number of houses) could be recommended. According to our experience vacuum backs or floor samples are not suitable for toxicological evaluation of inhaled exposure due to high amount of contaminants originating from other sources. Overall, this kind of study offers a unique opportunity to conduct in-depth indoor air studies producing crucial new information for development of tools that can be utilized in assessment of the potential health risks related to moisture damaged buildings." @default.
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• W2185366901 date "2008-01-01" @default.
• W2185366901 modified "2023-09-27" @default.
• W2185366901 title "Exposure to micro organisms - scientific needs for risk evaluation" @default.
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