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• W2185375995 abstract "Deep brain stimulation (DBS) of the ventrolateral thalamus stops several forms of tremor. Microelectrode recordings in the human thalamus have revealed tremor cells that fire synchronous with electromyographic tremor. The efficacy of DBS likely depends on its ability to modify the activity of these tremor cells either synaptically by stopping afferent tremor signals or by directly altering the intrinsic membrane currents of the neurons. To test these possibilities, whole-cell patch-clamp recordings of ventral thalamic neurons were obtained from rat brain slices. DBS was simulated (sDBS) using extracellular constant current pulse trains (125 Hz, 60‐80 s, 0.25‐5 mA, 1‐30 s) applied through a bipolar electrode. Using a paired-pulse protocol, we first established that thalamocortical relay neuronsreceiveconverginginputfrommultipleindependentafferentfibers.Second,althoughsDBSinducedhomosynapticdepression ofEPSPsalongitsownpathway,itdidnotaltertheresponsefromasecondindependentpathway.Third,incontrasttothesubthalamic nucleus, sDBS in the thalamus failed to inhibit the rebound potential and the persistent Na current but did activate the Ih current. Finally,ineightpatientsundergoingthalamicDBSsurgeryforessentialtremor,microstimulationwasmosteffectiveinalleviatingtremor when applied in close proximity to recorded tremor cells. However, stimulation could still suppress tremor at distances incapable of directly spreading to recorded tremor cells. These complementary data indicate that DBS may induce a “functional deafferentation” of afferentaxonstothalamictremorcells,therebypreventingtremorsignalpropagationinhumans." @default.
• W2185375995 created "2016-06-24" @default.
• W2185375995 creator A5063029101 @default.
• W2185375995 date "2006-01-01" @default.
• W2185375995 modified "2023-09-22" @default.
• W2185375995 title "SelectiveAttenuationofAfferentSynapticTransmissionasa MechanismofThalamicDeepBrainStimulation-Induced TremorArrest" @default.
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• W2185375995 hasPublicationYear "2006" @default.
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