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• W2185380638 abstract "The present study investigated the effects of repeated tramadol administration in 60 male rats. The animals were randomly divided into 6 equal groups (n=10/group). The first group served as control and administered saline solution only along the study. The remaining groups were administered oral doses of tramadol (tramadol HCl) suspended in saline solution equal to 40, 80, 120,160 and 200 mg/kg /daily for 60 days respectively. Liver and kidney functions, sex hormones activity, some neurochemical parameters in addition to some histopathological changes of the rat testes and brain tissues were studied. The results of the present experiment revealed a significant gradual increase in the serum ALT, AST and creatinine by increasing the dose of tramadol, the same result obtained for PRL and E2 in male rats. While tramadol significantly reduced serum LH, FSH and testosterone activities gradually however, 200 mg/kg showed the lowest levels. Repeated administration of tramadol also increased the density of α1–adrenoceptors in the rat brain cortex, as measured by saturation analysis of [3H] prazosin binding resembling to the effects induced by conventional antidepressants. The histopathological examination of testes revealed severe diffused testicular degeneration, the histopathological lesions were aggravated till testicular tissues calcification according to the dosing of tramadol (40, 80, 120, 160 and 200 mg/ kg.b.wt.). Brain tissues in all treated groups showed slight congestion of submeningeal blood vessels and neural degeneration. The histopathological alterations of testes and brain tissues and the above findings threw lights on the possible risks of increased hepatic, renal and neurological damages and sexual dysfunction evoked by repeated administration of tramadol for long periods." @default.
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• W2185380638 date "2014-01-01" @default.
• W2185380638 modified "2023-09-23" @default.
• W2185380638 title "Some Biochemical, Neurochemical, Pharmacotoxicological and Histopathological Alterations Induced by Long-term Administration of Tramadol in Male Rats" @default.
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