FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2185430857> ?p ?o ?g. }

• W2185430857 endingPage "63" @default.
• W2185430857 startingPage "53" @default.
• W2185430857 abstract "Seven prenylated 6a-hydroxy-pterocapans and five prenylated 6a,11a-pterocarpenes with different kinds of prenylation were purified from an ethanolic extract of fungus-treated soybean sprouts. The activity of these compounds toward both human estrogen receptors (hERα and hERβ) was determined in a yeast bioassay and the activity toward hERα was additionally tested in an U2-OS based hERα CALUX bioassay. In the yeast bioassay, compounds with chain prenylation showed in general an agonistic mode of action toward hERα, whereas furan and pyran prenylation led to an antagonistic mode of action. Five of these antagonistic compounds had an agonistic mode of action in the U2-OS based hERα CALUX bioassay, implying that these compounds can act as SERMs. The yeast bioassay also identified 8 ER subtype-selective compounds, with either an antagonistic mode of action or no response toward hERα and an agonistic mode of action toward hERβ. The ER subtype-selective compounds were characterized by 6a-hydroxy-pterocarpan or 6a,11a-pterocarpene backbone structure. It is suggested that either the extra D-ring or the increase in length to 12-13.5Å of these compounds is responsible for an agonistic mode of action toward hERβ and, thereby, inducing ER subtype-selective behavior." @default.
• W2185430857 created "2016-06-24" @default.
• W2185430857 creator A5001138315 @default.
• W2185430857 creator A5016397696 @default.
• W2185430857 creator A5027089451 @default.
• W2185430857 creator A5028263371 @default.
• W2185430857 creator A5039258379 @default.
• W2185430857 creator A5068140318 @default.
• W2185430857 date "2016-02-01" @default.
• W2185430857 modified "2023-10-02" @default.
• W2185430857 title "Glyceollins and dehydroglyceollins isolated from soybean act as SERMs and ER subtype-selective phytoestrogens" @default.
• W2185430857 cites W1642413975 @default.
• W2185430857 cites W1929711108 @default.
• W2185430857 cites W1939905704 @default.
• W2185430857 cites W1991921943 @default.
• W2185430857 cites W1994160613 @default.
• W2185430857 cites W1997103783 @default.
• W2185430857 cites W1999896243 @default.
• W2185430857 cites W2034200923 @default.
• W2185430857 cites W2034329390 @default.
• W2185430857 cites W2041958292 @default.
• W2185430857 cites W2042408301 @default.
• W2185430857 cites W2046746362 @default.
• W2185430857 cites W2068152759 @default.
• W2185430857 cites W2070021310 @default.
• W2185430857 cites W2075374439 @default.
• W2185430857 cites W2083131827 @default.
• W2185430857 cites W2085867277 @default.
• W2185430857 cites W2087459011 @default.
• W2185430857 cites W2087617801 @default.
• W2185430857 cites W2091429707 @default.
• W2185430857 cites W2097702778 @default.
• W2185430857 cites W2102403182 @default.
• W2185430857 cites W2103355388 @default.
• W2185430857 cites W2109737489 @default.
• W2185430857 cites W2112629831 @default.
• W2185430857 cites W2116095660 @default.
• W2185430857 cites W2127677509 @default.
• W2185430857 cites W2159274429 @default.
• W2185430857 cites W2325096632 @default.
• W2185430857 cites W2332059976 @default.
• W2185430857 cites W4211205139 @default.
• W2185430857 doi "https://doi.org/10.1016/j.jsbmb.2015.11.020" @default.
• W2185430857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26655113" @default.
• W2185430857 hasPublicationYear "2016" @default.
• W2185430857 type Work @default.
• W2185430857 sameAs 2185430857 @default.
• W2185430857 citedByCount "27" @default.
• W2185430857 countsByYear W21854308572016 @default.
• W2185430857 countsByYear W21854308572017 @default.
• W2185430857 countsByYear W21854308572018 @default.
• W2185430857 countsByYear W21854308572019 @default.
• W2185430857 countsByYear W21854308572020 @default.
• W2185430857 countsByYear W21854308572021 @default.
• W2185430857 countsByYear W21854308572022 @default.
• W2185430857 countsByYear W21854308572023 @default.
• W2185430857 crossrefType "journal-article" @default.
• W2185430857 hasAuthorship W2185430857A5001138315 @default.
• W2185430857 hasAuthorship W2185430857A5016397696 @default.
• W2185430857 hasAuthorship W2185430857A5027089451 @default.
• W2185430857 hasAuthorship W2185430857A5028263371 @default.
• W2185430857 hasAuthorship W2185430857A5039258379 @default.
• W2185430857 hasAuthorship W2185430857A5068140318 @default.
• W2185430857 hasConcept C104488531 @default.
• W2185430857 hasConcept C118552586 @default.
• W2185430857 hasConcept C121587506 @default.
• W2185430857 hasConcept C181199279 @default.
• W2185430857 hasConcept C185592680 @default.
• W2185430857 hasConcept C187898756 @default.
• W2185430857 hasConcept C2779222958 @default.
• W2185430857 hasConcept C2779448149 @default.
• W2185430857 hasConcept C54355233 @default.
• W2185430857 hasConcept C55493867 @default.
• W2185430857 hasConcept C57790582 @default.
• W2185430857 hasConcept C71240020 @default.
• W2185430857 hasConcept C71924100 @default.
• W2185430857 hasConcept C86803240 @default.
• W2185430857 hasConcept C98274493 @default.
• W2185430857 hasConceptScore W2185430857C104488531 @default.
• W2185430857 hasConceptScore W2185430857C118552586 @default.
• W2185430857 hasConceptScore W2185430857C121587506 @default.
• W2185430857 hasConceptScore W2185430857C181199279 @default.
• W2185430857 hasConceptScore W2185430857C185592680 @default.
• W2185430857 hasConceptScore W2185430857C187898756 @default.
• W2185430857 hasConceptScore W2185430857C2779222958 @default.
• W2185430857 hasConceptScore W2185430857C2779448149 @default.
• W2185430857 hasConceptScore W2185430857C54355233 @default.
• W2185430857 hasConceptScore W2185430857C55493867 @default.
• W2185430857 hasConceptScore W2185430857C57790582 @default.
• W2185430857 hasConceptScore W2185430857C71240020 @default.
• W2185430857 hasConceptScore W2185430857C71924100 @default.
• W2185430857 hasConceptScore W2185430857C86803240 @default.
• W2185430857 hasConceptScore W2185430857C98274493 @default.
• W2185430857 hasLocation W21854308571 @default.
• W2185430857 hasLocation W21854308572 @default.
• W2185430857 hasOpenAccess W2185430857 @default.
• W2185430857 hasPrimaryLocation W21854308571 @default.
• W2185430857 hasRelatedWork W1980901051 @default.

• next