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• W2185432271 abstract "SUMMARY In 1981, R. Edgar Hope-Simpson proposed that a ‘seasonal stimulus ’ intimately associated with solar radiation explained the remarkable seasonality of epidemic influenza. Solar radiation triggers robust seasonal vitamin D production in the skin ; vitamin D deficiency is common in the winter, and activated vitamin D, 1,25(OH)2D, a steroid hormone, has profound effects on human immunity. 1,25(OH)2D acts as an immune system modulator, preventing excessive expression of inflammatory cytokines and increasing the ‘oxidative burst ’ potential of macrophages. Perhaps most importantly, it dramatically stimulates the expression of potent anti-microbial peptides, which exist in neutrophils, monocytes, natural killer cells, and in epithelial cells lining the respiratory tract where they play a major role in protecting the lung from infection. Volunteers inoculated with live attenuated influenza virus are more likely to develop fever and serological evidence of an immune response in the winter. Vitamin D deficiency predisposes children to respiratory infections. Ultraviolet radiation (either from artificial sources or from sunlight) reduces the incidence of viral respiratory infections, as does cod liver oil (which contains vitamin D). An interventional study showed that vitamin D reduces the incidence of respiratory infections in children. We conclude that vitamin D, or lack of it, may be Hope-Simpson’s ‘seasonal stimulus ’." @default.
• W2185432271 created "2016-06-24" @default.
• W2185432271 creator A5069313220 @default.
• W2185432271 creator A5089503594 @default.
• W2185432271 date "2006-01-01" @default.
• W2185432271 modified "2023-09-26" @default.
• W2185432271 title "REVIEW ARTICLE Epidemic influenza and vitamin D" @default.
• W2185432271 cites W1004134193 @default.
• W2185432271 cites W105434507 @default.
• W2185432271 cites W126660711 @default.
• W2185432271 cites W1502615329 @default.
• W2185432271 cites W1523679951 @default.
• W2185432271 cites W152404013 @default.
• W2185432271 cites W1873207088 @default.
• W2185432271 cites W1880337221 @default.
• W2185432271 cites W1896241922 @default.
• W2185432271 cites W1960753282 @default.
• W2185432271 cites W1971756895 @default.
• W2185432271 cites W1972181361 @default.
• W2185432271 cites W1972303745 @default.
• W2185432271 cites W1973978680 @default.
• W2185432271 cites W1974262092 @default.
• W2185432271 cites W1975844832 @default.
• W2185432271 cites W1978342536 @default.
• W2185432271 cites W1980875416 @default.
• W2185432271 cites W1982857420 @default.
• W2185432271 cites W1983027239 @default.
• W2185432271 cites W1985741936 @default.
• W2185432271 cites W1988399483 @default.
• W2185432271 cites W1993261322 @default.
• W2185432271 cites W1994581378 @default.
• W2185432271 cites W1996055041 @default.
• W2185432271 cites W1996563641 @default.
• W2185432271 cites W2002801487 @default.
• W2185432271 cites W2004695175 @default.
• W2185432271 cites W2007214754 @default.
• W2185432271 cites W2011277158 @default.
• W2185432271 cites W2016241244 @default.
• W2185432271 cites W2027990211 @default.
• W2185432271 cites W2028489075 @default.
• W2185432271 cites W2036414847 @default.
• W2185432271 cites W2036768931 @default.
• W2185432271 cites W2040462732 @default.
• W2185432271 cites W2040837263 @default.
• W2185432271 cites W204123306 @default.
• W2185432271 cites W2042559380 @default.
• W2185432271 cites W2050196352 @default.
• W2185432271 cites W2050713822 @default.
• W2185432271 cites W2054579523 @default.
• W2185432271 cites W2057198053 @default.
• W2185432271 cites W2058144955 @default.
• W2185432271 cites W2063315156 @default.
• W2185432271 cites W2070187298 @default.
• W2185432271 cites W2076582712 @default.
• W2185432271 cites W2078275052 @default.
• W2185432271 cites W2080341187 @default.
• W2185432271 cites W2081552783 @default.
• W2185432271 cites W2083263009 @default.
• W2185432271 cites W2087696228 @default.
• W2185432271 cites W2088886718 @default.
• W2185432271 cites W2092073971 @default.
• W2185432271 cites W2092410657 @default.
• W2185432271 cites W2097587314 @default.
• W2185432271 cites W2098163460 @default.
• W2185432271 cites W2098369481 @default.
• W2185432271 cites W2100349034 @default.
• W2185432271 cites W2100626233 @default.
• W2185432271 cites W210101591 @default.
• W2185432271 cites W2103777411 @default.
• W2185432271 cites W2106114487 @default.
• W2185432271 cites W2106449126 @default.
• W2185432271 cites W2106459551 @default.
• W2185432271 cites W2108906307 @default.
• W2185432271 cites W2110521677 @default.
• W2185432271 cites W2120035496 @default.
• W2185432271 cites W2121600945 @default.
• W2185432271 cites W2122087180 @default.
• W2185432271 cites W2122399224 @default.
• W2185432271 cites W2122988122 @default.
• W2185432271 cites W2124352477 @default.
• W2185432271 cites W2124580054 @default.
• W2185432271 cites W2125222551 @default.
• W2185432271 cites W2126615685 @default.
• W2185432271 cites W2130703653 @default.
• W2185432271 cites W2134438238 @default.
• W2185432271 cites W2135815514 @default.
• W2185432271 cites W2138328097 @default.
• W2185432271 cites W2139853234 @default.
• W2185432271 cites W2141632987 @default.
• W2185432271 cites W2142183082 @default.
• W2185432271 cites W2142971300 @default.
• W2185432271 cites W2143149599 @default.
• W2185432271 cites W2144737041 @default.
• W2185432271 cites W2147127751 @default.
• W2185432271 cites W2150499174 @default.
• W2185432271 cites W2155228191 @default.
• W2185432271 cites W2159251846 @default.
• W2185432271 cites W2162256663 @default.
• W2185432271 cites W2163468378 @default.
• W2185432271 cites W2163892208 @default.

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