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- W2185444787 abstract "Central haemodynamics atrestandduring exercise werestudied in14malepatients withmoderate essential hypertension. Their circulatory state was studied before andimmediately after intravenous administration ofpropranolol, 0.2mg/kg bodyweight. In8ofthepatients anidentical study wasrepeated after .2months oforal propranolol therapy. Thissecond study wasperformed whentheoraltherapy hadbeendiscontinued for>72hours whichexceeds thetime necessary forcomplete metabolism andexcretion ofpropranolol. Pulmonary oxygenuptake, arteriovenous oxygendifference, heart rate,andblood pressures inthesubclavian artery, pulmonary artery, pulmonary wedge position, andright atrium weremeasured. Before oral treatment, propranolol injection caused significant reductions ofoxygenuptake (5%), heart rate( 13%),cardiac output( 20%),andstroke volume(- 10%),significant increments to systemic (35/3%) andpulmonary vascular resistance (- 35%)° , andincreased filling pressures forboth ventricles during exercise. After long-term treatment andomission ofthedrug, thespontaneous heart ratesatrestandduring exercise weresignificantly lower thanbefore treatment. Propranolol injection now still increased theventricular filling pressures atexercise butcaused nosignificant effects on oxygenuptake, heart rate,cardiac output, stroke volume, orsystemic vascular resistance. Itisconcluded thatlong-term beta-receptor blockade leads toa physiological adaptation including a persistent relative bradycardia and almost complete abolition ofthehaemodynamic response toacuteadninistration ofabeta-receptor blocking agent.Itissuggested that this adaptation, which resembles that of physical training, constitutes one mechanism whereby long-term beta-receptor blockade isable toreduce thearterial blood pressure." @default.
- W2185444787 created "2016-06-24" @default.
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- W2185444787 date "1976-01-01" @default.
- W2185444787 modified "2023-09-26" @default.
- W2185444787 title "Effects remaining after withdrawal oflong-term beta-receptor blockade Reduced heart rateandaltered haemodynamic response toacutepropranolol administration'" @default.
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