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- W2185448575 abstract "Summary Th estandar dmetho do fpeptid elibrar ysynthesi sinvolve scouplin gstep si nwhic h asingl eamin oaci di sreacted wit h amixtur eo fresin-boun damin oacids .Th emor erecentl ydescribe dpositiona lscannin gstrateg y(i nwhich eac hpositio ni nth epeptid esequenc ei soccupie di ntur nb y asingl eresidue )i sdifferen tsinc ei tinvolve sthe couplin go fmixture so famin oacid st omixture so fresin-boun damin oacids .I nth epresen tstudy ,w eanalyze th ecompound sproduce dunde rthes econdition smeasurin gcouplin grate san damount so fforme dproducts ,using mainl yUV ,HPLC ,LC/M San dMS/M Stechniques .Ou rdat ad ono tpermi tt oconclud etha tth eresultin glibraries ar ecomplete .Indeed ,ou ranalytica ldat aindicat etha t alarg epar to fth edi- ,tri -an dtetrapeptide ssynthesized wit hthi smetho dar eno tpresen ti nth efina lmixture .Althoug hchemica lcompensatio n(i nwhic hpoo rcoupling kinetic si scompensate db y alarge rexces so fth eincomin gamin oacid )ha sbee nthough tt ocounterbalanc ethese biases ,ou rexperiment ssho wtha tth ecompensatio nmetho ddoe sno ttak eint oaccoun tth ecrucia linfluenc eo fthe resin-boun damin oaci dan dtha teve nth edipeptid elibrarie sobtaine di nthi swa yar efa rfro mcompleteness .The presen twor kprovide sstron gevidenc etha tth ecouplin go fmixture so famin oacid st oresin-boun dresidues ,which i srequire db yth epositiona lscannin gstrategy ,result si nincomplet eand/o rnon-equimola rlibraries .I tals oclearly confirm stha tcouplin grate si nsolid-phas epeptid esynthesi sar edependen to nth enatur eo fbot hth eincomin gand th eimmobilize damin oacid. Abbreviations :DCCI ,N,N -dicyclohexylcarbodiimide ;DCM ,dichloromethane ;DMF ,N,N-dimethylformamide; DTT ,dithiothreitol ;ESI ,electrospray ;HOBt ,hydroxybenzotriazole ;MS ,mas sspectrometry ;MS/MS ,tande mmass spectrometry ;Pmc ,2,2,5,7,8-pentamethyl-chroman-6-sulfonyl ;TFA ,trifluoroaceti cacid ;Trt ,triphenylmethyl" @default.
- W2185448575 created "2016-06-24" @default.
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- W2185448575 date "1997-01-01" @default.
- W2185448575 modified "2023-09-27" @default.
- W2185448575 title "Limitation so fth ecouplin go famin oaci dmixture sfo rth epreparatio nof equimola rpeptid elibraries" @default.
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