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- W2185457907 abstract "Rapidly emerging resistance to the broad-spectrum β-lactams, mediated by extended-spectrum β-lactamases (ESBLs), is an increasing problem worldwide. This problem has been characterised by difficulties in the recognition of ESBL-producing strains in the laboratory, particularly by rapid susceptibility test methods. In many cases routine susceptibility testing fails to detect resistance due to ESBL production in strains that remain apparently susceptible to ceftazidime or cefotaxime at the breakpoints advocated by the NCCLS (8 to 16 µg/ml). At the same time, clinical data demonstrate in vivo resistance of ESBL producers to oxyimino-β-lactams regardless of the actual susceptibility found. This bags the question of the best way to detect ESBL producers. Several tests based on on the sensitivity of class A ESBLs to β-lactamase inhibitors such as clavulanic acid have been used in laboratory practice, including a double -disk synergy test and E-test® ESBL (AB BIODISK, Sweden). The latter method allows detection of ESBL producers using the MIC ratio of ceftazidime alone (TZ) and its combination with clavulanic acid (TZL) as a discriminative criterion." @default.
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- W2185457907 date "1997-01-01" @default.
- W2185457907 modified "2023-09-26" @default.
- W2185457907 title "Interpretation of Results of ESBL Detection Using E-test ® Needs in Consensus" @default.
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