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- W2185464414 abstract "Iodothyronamide (T1AM) is a naturally produced endogenous hormone like molecule. Only recently it has been discovered in the past decade, the proceeding body of research emerging from its initial discovery has revealed a substantial capacity of T1AM as a new potential hormone that affects numerous physiological processes and organs. Initially, it was hypothesized to be a byproduct of Thyroid Hormone (TH) metabolism; however, the current body of evidence suggests that its production and physiological function appear to be uncoupled and dramatically divergent from that of TH. This review summarizes the physiological and biochemical effects of T1AM reported in the literature along with its proposed mechanisms of action and production pathways. The physiological effects of T1AM appear to be dose specific, in some cases exerting opposing effects in the same biological processes. Uptake, storage, and degree of effect appear to be tissue specific as well. From the current body of literature, potential therapeutic applications with T1AM are quite apparent, ranging from sleep/torpidity induction, conferring protection against ischemic injury, and anti-obesogenic by inducing increased metabolic reliance on lipid oxidation. Future research is needed to understand the specific mechanisms of its dose dependent and tissue dependent effects, its mechanism of entry into the cell, its cellular targets, and primary site of production." @default.
- W2185464414 created "2016-06-24" @default.
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- W2185464414 date "2015-01-01" @default.
- W2185464414 modified "2023-10-14" @default.
- W2185464414 title "3-Iodothyronamine: A High Potency Metabolic Hormone and its Potential for Therapeutic Applications" @default.
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- W2185464414 doi "https://doi.org/10.15226/2374-6890/2/1/00116" @default.
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