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• W2185472904 abstract "Abstract A Th2-skewed immunity may be necessary for a successful pregnancy and the ability to easily direct immune responses to a Th2-polarized profile may be an evolutionary benefit. The Th2-like immunity associated with allergic disease might generate favourable effects on the maintenance of pregnancy, but also on the development of Th2-like immune responses and allergic disease in the offspring. The aim of this study was to explore, by using IgE as a stable proxy for Th2, the Th1/Th2 balance in allergic and non-allergic women by measuring specific and total IgE antibody levels during pregnancy and after delivery. The specific and total IgE antibody levels were determined by ImmunoCAP technology at five occasions during pregnancy (at gestational week 10-12, 15-16, 25, 35 and 39), as well as 2 and 12 months after delivery. Thirty-six women without and 20 women with allergic symptoms were included, of whom 13 were sensitised with allergic symptoms and 30 non-sensitised without allergic symptoms. The levels of total IgE, but not specific IgE, were increased during early pregnancy, as compared to 12 months after delivery, in the sensitised women with allergic symptoms, but not in the non-sensitised women without allergic symptoms (p<0.01). The increase in total IgE levels during early pregnancy only in the sensitised women with allergic symptoms indicates that allergy is associated with an enhanced Th2 deviation during pregnancy." @default.
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• W2185472904 date "2009-01-01" @default.
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• W2185472904 title "Linköping University Post Print Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy" @default.
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