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• W2185488001 abstract "Backgrounds Previous studies have shown inconsistent results regarding the efficacy of homocysteine- lowering therapy with folic acid for reduction of cardiovascular risk, particularly in populations with chronic kidney disease (CKD). Methods We conducted a meta-analysis of clinical trials performed between January 1966 and December 2012 to assess the effects of folic acid supplementation in CKD populations. Data from 10 randomized controlled trials including 8879 patients with CKD were analysed. Results Different degrees of homocysteine reduction were achieved in all studies. A total of 1619 cardiovascular events were reported, and a beneficial trend but no statistical significance of homocysteine-lowering therapy with folic acid on reduction of cardiovascular events was shown (relative risk (RR), 0.93; 95% CI, 0.83 to 1.05; P=0.23). Subgroup analyses of cardiovascular events showed a statistical benefit in populations with end-stage renal disease and no folic acid fortification (RR, 0.82; 95% CI, 0.68 to 0.99; and RR, 0.74; 95% CI, 0.56 to 0.96, respectively), and a beneficial trend but no statistical significance was shown in populations with a high baseline homocysteine concentration, greater degree of homocysteine lowering, low baseline albumin concentration, and low incidence of diabetes mellitus. There were 1980 deaths, which was not significant (RR, 1.03; 95% CI, 0.96 to 1.10; P=0.46). Nonsignificant results were also observed for myocardial infarction, stroke events, and vascular mortality. Conclusions A beneficial trend but no statistical significance was observed for reduction of cardiovascular risks with folic acid supplementation in populations with CKD. Statistical benefits were demonstrated in some patients, which should encourage further discussion." @default.
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• W2185488001 date "2013-01-01" @default.
• W2185488001 modified "2023-09-24" @default.
• W2185488001 title "A meta analysis of randomized controlled clinical trials of role of folic acid in cardiovascular risks in chronic kidney disease patients A shortened version of the paper's title: a meta-analysis of folate in patients with CKD" @default.
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