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• W2185503246 startingPage "135" @default.
• W2185503246 abstract "In order to characterize the transition of the corpora lutea (CL) from acquisition of luteolytic sensitivity to rescue of luteal function: i) the expression of 38 factors associated with steroids, prostanoids, and angiogenic systems and ii) concentrations of the main hormones responsible for maintenance of CL function in cyclic and pregnant pigs were examined. Additionally, the effect of prostaglandin (PG) E 2 and F 2 α on luteal function during the estrous cycle and pregnancy was evaluated in vitro . Significantly up-regulated gene expression was revealed in CL collected on day 14 of the estrous cycle ( CYP19A1 , ESR2 , PTGS2 , HIF1A , and EDN1 ) and on days 12–14 of pregnancy ( SCARB1 , PGRMC1 , STAR , HSD3B1 , NR5A1 , PTGFR , PTGER4 , and VEGFA ). Elevated concentrations of estradiol-17β and PGE 2 occurred in CL on days 12 and 14 of pregnancy respectively, while an increased intraluteal PGF 2 α content was noted on day 14 of the estrous cycle. Both PGs increased the synthesis of progesterone by cultured luteal slices obtained on day 14 of pregnancy, in contrast to the action of PGF 2 α on the corresponding day of the estrous cycle. PGE 2 stimulated cAMP production via PTGER2 and PTGER4, while PGF 2 α elevated the content of CREB in cultured luteal slices from CL of pregnant pigs. In silico analysis showed that infiltration of lymphocytes and apoptosis of microvascular endothelium were activated in CL on day 12 of the estrous cycle vs pregnancy. Summarizing, an abundance of E 2 and PGE 2 during pregnancy regulates specific pathways responsible for steroidogenesis, the prostanoid signaling system and angiogenesis during rescue from luteolysis in porcine CL." @default.
• W2185503246 created "2016-06-24" @default.
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• W2185503246 date "2016-02-01" @default.
• W2185503246 modified "2023-10-16" @default.
• W2185503246 title "Steroid hormones, prostanoids, and angiogenic systems during rescue of the corpus luteum in pigs" @default.
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• W2185503246 doi "https://doi.org/10.1530/rep-15-0332" @default.
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