FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2185552507> ?p ?o ?g. }

• W2185552507 abstract "Amino-adenosine (8-NH2-Ado)isaribosesugarnucleoside analoguethatreducescellularATPlevelsand inhibits mRNA synthesis. Estrogen receptor-negative (ER� ) metastatic breast cancers often contain mutant p53; therefore, we asked if 8-NH2-Ado could kill breast cancer cells without activating the p53-pathway. Regardless of the breast cancer subtype tested or the p53 status of the cells, 8-NH2-Ado was more cytotoxic than either gemcitabine or etoposide. 8-NH2-Ado treatment inhibited cell proliferation, activated cell death, and did not activate transcription of the p53 target gene p21 or increase protein levels of either p53 or p21. This occurred in the estrogen receptor-positive (ERþ) MCF-7 cells that express wild-type p53, the ERþ T47-D cells that express mutant p53, and the ERMDA-MB-468 cells or MDA-MB-231 cells that both express mutant p53. 8-NH2-Ado induced apoptotic death of MCF-7 cells and apoptosis was not inhibited by knockdown of functional p53. Moreover, the pan-caspase inhibitor Z-VAD blocked the 8-NH2-Ado-induced MCF-7 cell death. Interestingly, 8-NH2-Ado caused the MDA-MB-231 cells to detach from the plate with only limited evidence of apoptotic cell death markers and the cell death was not inhibited by Z-VAD. Inhibition of MDA- MB-231 cell autophagy, by reduction of ATG7 or 3-methyladenine treatment, did not block this 8-NH2-Ado- mediated cytotoxicity. Importantly 8-NH2-Ado was highly cytotoxic to triple-negative breast cancer cells and worked through a pathway that did not require wild-type p53 for cytoxicity. Therefore, 8-NH2-Ado should be considered for thetreatment of triple-negative breast cancers thatare chemotherapy resistant.MolCancer Ther; 11(11); 2495-504. � 2012 AACR." @default.
• W2185552507 created "2016-06-24" @default.
• W2185552507 creator A5001354914 @default.
• W2185552507 creator A5013430443 @default.
• W2185552507 creator A5040207363 @default.
• W2185552507 creator A5050128762 @default.
• W2185552507 creator A5059233366 @default.
• W2185552507 creator A5085111319 @default.
• W2185552507 date "2012-01-01" @default.
• W2185552507 modified "2023-09-27" @default.
• W2185552507 title "8-Amino-AdenosineActivatesp53-IndependentCellDeathof Metastatic Breast Cancers" @default.
• W2185552507 cites W1784425676 @default.
• W2185552507 cites W1968075505 @default.
• W2185552507 cites W1970249544 @default.
• W2185552507 cites W1989051519 @default.
• W2185552507 cites W1991451193 @default.
• W2185552507 cites W1996593753 @default.
• W2185552507 cites W2011892634 @default.
• W2185552507 cites W2014750426 @default.
• W2185552507 cites W2024677192 @default.
• W2185552507 cites W2038921550 @default.
• W2185552507 cites W2041033535 @default.
• W2185552507 cites W2047303826 @default.
• W2185552507 cites W2049528479 @default.
• W2185552507 cites W2054549064 @default.
• W2185552507 cites W2083738732 @default.
• W2185552507 cites W2090451989 @default.
• W2185552507 cites W2097299115 @default.
• W2185552507 cites W2099987999 @default.
• W2185552507 cites W2106888057 @default.
• W2185552507 cites W2108568329 @default.
• W2185552507 cites W2111773529 @default.
• W2185552507 cites W2119349084 @default.
• W2185552507 cites W2121415861 @default.
• W2185552507 cites W2122744674 @default.
• W2185552507 cites W2124135816 @default.
• W2185552507 cites W2129019688 @default.
• W2185552507 cites W2135574023 @default.
• W2185552507 cites W2142739240 @default.
• W2185552507 cites W2149306102 @default.
• W2185552507 cites W2151147112 @default.
• W2185552507 cites W2164387057 @default.
• W2185552507 cites W2510982895 @default.
• W2185552507 hasPublicationYear "2012" @default.
• W2185552507 type Work @default.
• W2185552507 sameAs 2185552507 @default.
• W2185552507 citedByCount "0" @default.
• W2185552507 crossrefType "journal-article" @default.
• W2185552507 hasAuthorship W2185552507A5001354914 @default.
• W2185552507 hasAuthorship W2185552507A5013430443 @default.
• W2185552507 hasAuthorship W2185552507A5040207363 @default.
• W2185552507 hasAuthorship W2185552507A5050128762 @default.
• W2185552507 hasAuthorship W2185552507A5059233366 @default.
• W2185552507 hasAuthorship W2185552507A5085111319 @default.
• W2185552507 hasConcept C109316439 @default.
• W2185552507 hasConcept C121608353 @default.
• W2185552507 hasConcept C126322002 @default.
• W2185552507 hasConcept C154317977 @default.
• W2185552507 hasConcept C173396325 @default.
• W2185552507 hasConcept C190283241 @default.
• W2185552507 hasConcept C202751555 @default.
• W2185552507 hasConcept C31573885 @default.
• W2185552507 hasConcept C502942594 @default.
• W2185552507 hasConcept C530470458 @default.
• W2185552507 hasConcept C54355233 @default.
• W2185552507 hasConcept C55493867 @default.
• W2185552507 hasConcept C71924100 @default.
• W2185552507 hasConcept C81885089 @default.
• W2185552507 hasConcept C84606932 @default.
• W2185552507 hasConcept C86803240 @default.
• W2185552507 hasConcept C96232424 @default.
• W2185552507 hasConceptScore W2185552507C109316439 @default.
• W2185552507 hasConceptScore W2185552507C121608353 @default.
• W2185552507 hasConceptScore W2185552507C126322002 @default.
• W2185552507 hasConceptScore W2185552507C154317977 @default.
• W2185552507 hasConceptScore W2185552507C173396325 @default.
• W2185552507 hasConceptScore W2185552507C190283241 @default.
• W2185552507 hasConceptScore W2185552507C202751555 @default.
• W2185552507 hasConceptScore W2185552507C31573885 @default.
• W2185552507 hasConceptScore W2185552507C502942594 @default.
• W2185552507 hasConceptScore W2185552507C530470458 @default.
• W2185552507 hasConceptScore W2185552507C54355233 @default.
• W2185552507 hasConceptScore W2185552507C55493867 @default.
• W2185552507 hasConceptScore W2185552507C71924100 @default.
• W2185552507 hasConceptScore W2185552507C81885089 @default.
• W2185552507 hasConceptScore W2185552507C84606932 @default.
• W2185552507 hasConceptScore W2185552507C86803240 @default.
• W2185552507 hasConceptScore W2185552507C96232424 @default.
• W2185552507 hasLocation W21855525071 @default.
• W2185552507 hasOpenAccess W2185552507 @default.
• W2185552507 hasPrimaryLocation W21855525071 @default.
• W2185552507 hasRelatedWork W1577287732 @default.
• W2185552507 hasRelatedWork W2009884504 @default.
• W2185552507 hasRelatedWork W2017838943 @default.
• W2185552507 hasRelatedWork W2075962843 @default.
• W2185552507 hasRelatedWork W2092953996 @default.
• W2185552507 hasRelatedWork W2110374368 @default.
• W2185552507 hasRelatedWork W2132445323 @default.
• W2185552507 hasRelatedWork W2165843468 @default.
• W2185552507 hasRelatedWork W2274971803 @default.

• next