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- W2185556908 abstract "Trimetazidine dihydrochloride is absorbed quickly from immediate release dosage form and attains very low concentration in plasma at time of next dose. To maintain constant drug plasma level, matrix tablets were prepared with varying Methocel E grades and concentrations, and followed by their in vitro drug releases studies. The formulated products were also compared with marketed product for release behavior. Low viscosity Methocel formulated matrix tablets, F1 to F3 showed fast release of drug. F6 was best formulation which released drug for 12 h while high viscosity Methocel in F7 to F9 showed very slow drug release which extended for more than 12 h. release rate was also extended as concentration of Methocel was increased. Model fitting of the in vitro drug release studies suggests that formulations best fitted in first order release kinetics. Drug release from the matrix occurred by combination of two mechanisms, diffusion of drug from tablet matrix and erosion of drug from tablet surface, which was reflected from Higuchi's model." @default.
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- W2185556908 date "2012-01-01" @default.
- W2185556908 modified "2023-09-22" @default.
- W2185556908 title "FORMULATION AND EFFECT OF VISCOSITY AND CONCENTRATION OF METHOCEL ON RELEASE CHARACTERISTICS OF TRIMETAZIDINE MATRIX TABLETS Research Article" @default.
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