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- W2185586905 abstract "Benzodiazepines are the most preferred anxiolytics. Their activity as anxiolytics is mediated through central – type benzodiazepine receptor (CBR), which is associated with GABAA receptors and enhances the inhibitory effect of GABA. Another type of benzodiazepine receptors called peripheral-type benzodiazepine receptors (PBR) expressed exclusively on the outer membrane of mitochondria and functions mainly with steroidogenic machinery. Besides, PBR is involved in many other functions. The main theme of the present work has emanated from recent research that PBR ligand has another target distinct from PBR, which binds to oligomycine-sensitivity conferring Protein (OSCP) of mitochondrial F 1 -F 0 ATPase and reduces its activity, so that increasing the cellular free radicals thus acts as an anti-proliferative and pro-apoptotic. In the present work we evaluated the effect of diazepam (Valium, a PBR ligand) on goat epididymal spermatozoa taking ROS enhancement and diminution of F 1 -F 0" @default.
- W2185586905 created "2016-06-24" @default.
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- W2185586905 date "2013-01-01" @default.
- W2185586905 modified "2023-09-27" @default.
- W2185586905 title "Diazepam: a peripheral benzodiazepine receptor ligand, inhibits mitochondrial F 1 -F 0 ATPase and induces oxidative stress in goat epididymal sperm in vitro" @default.
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