FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2185623393> ?p ?o ?g. }

• W2185623393 endingPage "21" @default.
• W2185623393 startingPage "419" @default.
• W2185623393 abstract "Breast cancer has a strong genetic component, and at least two breast cancer genes exist. But these genes probably play little role in most breast cancers. Other factors, such as environmental estrogens and diet, may cause the genetic changes involved in the genesis of sporadic breast cancer. A method of observing genetic changes indirectly might be to measure tumor markers known to be associated with breast cancer.We measured, by biochemical extraction and partition, lipid-associated sialic acid in plasma (LASA-P), a circulating tumor marker, in a group of 239 women with benign or malignant breast tumors.The concentration of LASA-P was elevated in women with both benign and malignant tumors and no family history of breast cancer (p = 0.046, one-way ANOVA). Because LASA-P levels rise with age and number of pregnancies, we analyzed our data using multiple linear regression. Benign versus malignant character of the tumor, family history of breast cancer, number of pregnancies, and age were the independent variables. Family history of breast cancer had a significant effect on LASA-P levels (p = 0.0146) independent of the effects of age (p = 0.011), number of pregnancies (0.012), and whether the tumor was benign or malignant (p = 0.31).We hypothesize that elevated LASA-P in women with breast tumors and no family history of breast cancer is a result of the genetic changes occurring in nonfamilial breast cancer. These genetic changes, possibly related to environmental estrogens or other environmental factors, are distinct from the changes due to mutations of BRCA1 or other familial breast cancer genes. Moreover, the elevation of LASA-P suggests that the surface membranes of breast cancer may differ in composition. Further study may lead to exact characterization of the genetic and cell membrane changes associated with familial and nonfamilial breast tumors, and perhaps to better methods of breast cancer prevention and treatment." @default.
• W2185623393 created "2016-06-24" @default.
• W2185623393 creator A5009505942 @default.
• W2185623393 creator A5027802297 @default.
• W2185623393 creator A5066709689 @default.
• W2185623393 creator A5075008841 @default.
• W2185623393 creator A5086932223 @default.
• W2185623393 date "1995-11-01" @default.
• W2185623393 modified "2023-10-14" @default.
• W2185623393 title "Breast cancer and family history: levels of lipid-associated sialic acid in plasma and absent family history of breast cancer in women who have breast tumors." @default.
• W2185623393 cites W1536299500 @default.
• W2185623393 cites W1895246365 @default.
• W2185623393 cites W2005462468 @default.
• W2185623393 cites W2007568599 @default.
• W2185623393 cites W2012180988 @default.
• W2185623393 cites W2018756035 @default.
• W2185623393 cites W2026222149 @default.
• W2185623393 cites W2071916846 @default.
• W2185623393 cites W2088049062 @default.
• W2185623393 cites W2115109761 @default.
• W2185623393 cites W2136883708 @default.
• W2185623393 cites W2153579158 @default.
• W2185623393 cites W2154135601 @default.
• W2185623393 cites W1996990606 @default.
• W2185623393 cites W2514687308 @default.
• W2185623393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8692154" @default.
• W2185623393 hasPublicationYear "1995" @default.
• W2185623393 type Work @default.
• W2185623393 sameAs 2185623393 @default.
• W2185623393 citedByCount "2" @default.
• W2185623393 crossrefType "journal-article" @default.
• W2185623393 hasAuthorship W2185623393A5009505942 @default.
• W2185623393 hasAuthorship W2185623393A5027802297 @default.
• W2185623393 hasAuthorship W2185623393A5066709689 @default.
• W2185623393 hasAuthorship W2185623393A5075008841 @default.
• W2185623393 hasAuthorship W2185623393A5086932223 @default.
• W2185623393 hasConcept C121608353 @default.
• W2185623393 hasConcept C126322002 @default.
• W2185623393 hasConcept C143998085 @default.
• W2185623393 hasConcept C2781179581 @default.
• W2185623393 hasConcept C530470458 @default.
• W2185623393 hasConcept C71924100 @default.
• W2185623393 hasConceptScore W2185623393C121608353 @default.
• W2185623393 hasConceptScore W2185623393C126322002 @default.
• W2185623393 hasConceptScore W2185623393C143998085 @default.
• W2185623393 hasConceptScore W2185623393C2781179581 @default.
• W2185623393 hasConceptScore W2185623393C530470458 @default.
• W2185623393 hasConceptScore W2185623393C71924100 @default.
• W2185623393 hasIssue "6" @default.
• W2185623393 hasLocation W21856233931 @default.
• W2185623393 hasOpenAccess W2185623393 @default.
• W2185623393 hasPrimaryLocation W21856233931 @default.
• W2185623393 hasRelatedWork W106213372 @default.
• W2185623393 hasRelatedWork W2007291103 @default.
• W2185623393 hasRelatedWork W2082618958 @default.
• W2185623393 hasRelatedWork W2114537787 @default.
• W2185623393 hasRelatedWork W2324072814 @default.
• W2185623393 hasRelatedWork W2357436403 @default.
• W2185623393 hasRelatedWork W2740664066 @default.
• W2185623393 hasRelatedWork W2761643758 @default.
• W2185623393 hasRelatedWork W2920224970 @default.
• W2185623393 hasRelatedWork W3141800297 @default.
• W2185623393 hasVolume "62" @default.
• W2185623393 isParatext "false" @default.
• W2185623393 isRetracted "false" @default.
• W2185623393 magId "2185623393" @default.
• W2185623393 workType "article" @default.