Matches in SemOpenAlex for { <https://semopenalex.org/work/W2185626857> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2185626857 endingPage "6" @default.
- W2185626857 startingPage "63" @default.
- W2185626857 abstract "Chronic hepatitis C was a frequent complication in patients treated for malignancy until the introduction of anti-HCV screening tests for blood donors. The association between chronic hepatitis C and progression to cirrhosis and hepatocellular carcinoma has been reported in about 20% and 5% of patients, respectively, within 20-30 years of infection. In adult patients, interferon has proved to be effective in decreasing the abnormal values of transaminases and the level of HCV viremia. Our purpose was to assess efficacy of and tolerance to interferon in a group of young patients who had acquired HCV infection during a period of chemotherapy.Interferon-a (IFN) was administered to 26 adolescents and young adults (13 males, age range 17-36 years; median age 24) with chronic hepatitis C, including 4 with hepatitis B virus co-infection, who had been treated for leukemia or solid tumor 5 to 19 years before joining this trial. Patients were treated with natural IFN alpha at a dose of 4 MU/m(2) thrice weekly for 12 months and followed up for another 6 months thereafter.Nine patients stopped treatment during the first 6 months because of side effects (2 cases) or lack of response. At the end of the trial, 8 (31%) cases had responded, with alanine amino-transferase normalization and clearance of hepatitis C virus (HCV) RNA. A sustained response was only documented in 15% of cases, however, irrespective of any hepatitis B virus co-infection. The 2 patients with HCV genotype 2 were both responders, whereas only 8% of those with genotype 1 responded.These data show that the efficacy of IFN in this series of young patients is similar to that reported for otherwise healthy adults with hepatitis C. Patients with genotype 2 are strong candidates for IFN treatment while other therapeutic strategies should be designed for patients with HCV genotype 1." @default.
- W2185626857 created "2016-06-24" @default.
- W2185626857 creator A5003395478 @default.
- W2185626857 creator A5007063184 @default.
- W2185626857 creator A5008957297 @default.
- W2185626857 creator A5020243719 @default.
- W2185626857 creator A5020861863 @default.
- W2185626857 creator A5043021026 @default.
- W2185626857 creator A5054179969 @default.
- W2185626857 creator A5068934829 @default.
- W2185626857 creator A5073188215 @default.
- W2185626857 date "2000-01-01" @default.
- W2185626857 modified "2023-09-23" @default.
- W2185626857 title "Interferon treatment of chronic hepatitis C in patients cured of pediatric malignancies." @default.
- W2185626857 cites W1974498892 @default.
- W2185626857 cites W1982984345 @default.
- W2185626857 cites W1993141832 @default.
- W2185626857 cites W2020746683 @default.
- W2185626857 cites W2064603872 @default.
- W2185626857 cites W2069633422 @default.
- W2185626857 cites W2088103929 @default.
- W2185626857 cites W2098843059 @default.
- W2185626857 cites W2110309669 @default.
- W2185626857 cites W2155510029 @default.
- W2185626857 cites W2165715544 @default.
- W2185626857 cites W2317554121 @default.
- W2185626857 cites W2318639814 @default.
- W2185626857 cites W2335968781 @default.
- W2185626857 cites W2341829866 @default.
- W2185626857 cites W2345589250 @default.
- W2185626857 cites W2406992313 @default.
- W2185626857 cites W2413989818 @default.
- W2185626857 cites W3126246200 @default.
- W2185626857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10629594" @default.
- W2185626857 hasPublicationYear "2000" @default.
- W2185626857 type Work @default.
- W2185626857 sameAs 2185626857 @default.
- W2185626857 citedByCount "1" @default.
- W2185626857 crossrefType "journal-article" @default.
- W2185626857 hasAuthorship W2185626857A5003395478 @default.
- W2185626857 hasAuthorship W2185626857A5007063184 @default.
- W2185626857 hasAuthorship W2185626857A5008957297 @default.
- W2185626857 hasAuthorship W2185626857A5020243719 @default.
- W2185626857 hasAuthorship W2185626857A5020861863 @default.
- W2185626857 hasAuthorship W2185626857A5043021026 @default.
- W2185626857 hasAuthorship W2185626857A5054179969 @default.
- W2185626857 hasAuthorship W2185626857A5068934829 @default.
- W2185626857 hasAuthorship W2185626857A5073188215 @default.
- W2185626857 hasConcept C126322002 @default.
- W2185626857 hasConcept C203014093 @default.
- W2185626857 hasConcept C2522874641 @default.
- W2185626857 hasConcept C2776029263 @default.
- W2185626857 hasConcept C2776178377 @default.
- W2185626857 hasConcept C2776185481 @default.
- W2185626857 hasConcept C2776408679 @default.
- W2185626857 hasConcept C2776455275 @default.
- W2185626857 hasConcept C2776694085 @default.
- W2185626857 hasConcept C2777214474 @default.
- W2185626857 hasConcept C2778019345 @default.
- W2185626857 hasConcept C2781228144 @default.
- W2185626857 hasConcept C2909179924 @default.
- W2185626857 hasConcept C71924100 @default.
- W2185626857 hasConcept C90924648 @default.
- W2185626857 hasConceptScore W2185626857C126322002 @default.
- W2185626857 hasConceptScore W2185626857C203014093 @default.
- W2185626857 hasConceptScore W2185626857C2522874641 @default.
- W2185626857 hasConceptScore W2185626857C2776029263 @default.
- W2185626857 hasConceptScore W2185626857C2776178377 @default.
- W2185626857 hasConceptScore W2185626857C2776185481 @default.
- W2185626857 hasConceptScore W2185626857C2776408679 @default.
- W2185626857 hasConceptScore W2185626857C2776455275 @default.
- W2185626857 hasConceptScore W2185626857C2776694085 @default.
- W2185626857 hasConceptScore W2185626857C2777214474 @default.
- W2185626857 hasConceptScore W2185626857C2778019345 @default.
- W2185626857 hasConceptScore W2185626857C2781228144 @default.
- W2185626857 hasConceptScore W2185626857C2909179924 @default.
- W2185626857 hasConceptScore W2185626857C71924100 @default.
- W2185626857 hasConceptScore W2185626857C90924648 @default.
- W2185626857 hasIssue "1" @default.
- W2185626857 hasLocation W21856268571 @default.
- W2185626857 hasOpenAccess W2185626857 @default.
- W2185626857 hasPrimaryLocation W21856268571 @default.
- W2185626857 hasRelatedWork W1974433343 @default.
- W2185626857 hasRelatedWork W2001302624 @default.
- W2185626857 hasRelatedWork W2006454743 @default.
- W2185626857 hasRelatedWork W2023875365 @default.
- W2185626857 hasRelatedWork W2071402271 @default.
- W2185626857 hasRelatedWork W2275877922 @default.
- W2185626857 hasRelatedWork W2341014604 @default.
- W2185626857 hasRelatedWork W2374920454 @default.
- W2185626857 hasRelatedWork W2414025728 @default.
- W2185626857 hasRelatedWork W2409411072 @default.
- W2185626857 hasVolume "85" @default.
- W2185626857 isParatext "false" @default.
- W2185626857 isRetracted "false" @default.
- W2185626857 magId "2185626857" @default.
- W2185626857 workType "article" @default.