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• W2185631384 abstract "Chronic hepatitis C (HCV) is the most prevalent agent causing hepatic fibrosis in human. Laminin (LA) and INR have been related to liver fibrosis and subsequent development of portal hypertension. The aim of this study was to evaluate the clinical utility of serum laminin and INR ratio and to create a score which helps in the diagnoses of hepatic fibrosis in order to reduce the frequent biopsy. This study included three groups: group I included 20 voluntaries persons as a control, group II included 22 patients infected with HCV without fibrosis and group III included 50 patients infected with HCV with fibrosis. Serum laminin was assayed in different groups by ELISA and routine blood analysis included ALT, GGT, INR and platelets count. Significantly higher mean level for serum LA, ALT, GGT, INR and Platelets count in fibrotic and non-fibrotic patients were compared with control group. The discriminate score (DS=0.03 laminin + 4.2 INR - 7.3) result of ≥ 0 suggests that the patients had fibrosis and the sensitivity of this score is 90% and specificity is 77.3% and the accuracy is 86.1%. DS could be considered as an easy method for the diagnosis of hepatic fibrosis in the patients suffering from chronic active hepatitis C. However, this study is preliminary and it is recommend that investigation is carried out on large scale." @default.
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• W2185631384 date "2010-01-01" @default.
• W2185631384 modified "2023-09-24" @default.
• W2185631384 title "Clinical significance of serum laminin and INR ratio to diagnose fibrosis in patients with chronic active hepatitis C." @default.
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