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- W2185655230 abstract "The determination of efficient and improved procedures for the synthesis of N-protective groups in peptide synthesis using two types of reactive carbonates with different leaving groups (N,N’-disuccinimidyl carbonate and N,N’-diphthalimidyl carbonate) and different alcohols is reported. Good yields were obtained for succinimidyl derivatives because of the higher reactivity of N,N’-disuccinimidylcarbonate compared with N,N’-diphthalimidyl-carbonate. By using principles of the scientific programming of the laboratory experiments and by identifying the discrete and continuous variables that influence the processes, it has been achieved the improvement and optimization of the synthesis reactions yield and costs reduction." @default.
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- W2185655230 date "2013-01-01" @default.
- W2185655230 modified "2023-09-24" @default.
- W2185655230 title "Development of Economical and Efficient Mixed Reactive Carbonates for Peptide Synthesis through Scientific Planning" @default.
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