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- W2185655405 abstract "Objective: To investigate the potential of serratiopeptidase- a proteolytic enzyme, on acetic acid induced ulcerative colitis in mice. Methods: Ulcerative colitis was induced by acetic acid (6% v/v) injected into the colon to assess disease activity index which includes body weight loss, stool consistency and gross bleeding, colon length, spleen weights and histological changes were observed. Colon homogenates were subjected to measure myeloperoxidase enzyme levels, glutathione content, lipid peroxidation, and nitric oxide production. Results: Intra colonic administration of serratiopeptidase at both doses significantly reduce the disease activity index and also prevented colonic shortening, spleen enlargement, glutathione depletion and lipid peroxidation and nitric oxide production when compared with the colitis control groups. Conclusion: Present study results, confirms the serratiopeptidase antinflammatory activity against acetic acid induced ulcerative colitis." @default.
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- W2185655405 date "2014-01-01" @default.
- W2185655405 modified "2023-09-23" @default.
- W2185655405 title "INVESTIGATIONS ON THE POTENTIAL OF SERRATIOPEPTIDASE - A PROTEOLYTIC ENZYME, ON ACETIC ACID INDUCED ULCERATIVE COLITIS IN MICE" @default.
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