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• W2185683620 abstract "Summary POEMS syndrome is a rare paraneoplastic syndrome secondary to a plasma cell dyscrasia. Recognition of the complex of a combination of peri pheral neuropathy, organomegaly, endocrinopathy, monoclonal plasma proliferative dis order, skin changes, papilledema, extravascular volume overload (peripheral edema, pl eural effusions, and ascites), sclerotic bone lesions, thrombocytosis, and Castleman disease is t he first step in effectively managing the disease. A rise in the blood levels of vascular end othelial growth factor is usually confirmatory. More than 95% of patients will have monoclonal lambda sclerotic plasmacytoma(s) or bone marrow infiltration. In patients with a dominant sc lerotic plasmacytoma, first line therapy should include radiation to the lesion. Retrospective anal ysis and personal experience would dictate that systemic therapy be considered for patients with di ffuse sclerotic lesions or absence of any bone lesion and for those who have not demonstrated stab ilization of their disease 3 to 6 months after completing radiation therapy. For those patients wi th diffuse disease, systemic therapy is indicated. Useful approaches include therapy with c orticosteroids, low dose alkylator therapy, and high dose chemotherapy with peripheral blood st em cell transplant." @default.
• W2185683620 created "2016-06-24" @default.
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• W2185683620 date "2011-01-01" @default.
• W2185683620 modified "2023-09-27" @default.
• W2185683620 title "POEMS SYNDROME: A REVIEW" @default.
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