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- W2185688093 abstract "In this study, a well established expectancy manipulation model was combined with a novel placebo intervention, a validated sham acupunctureneedle,toinvestigatethebrainnetworkinvolvedinplaceboanalgesia.Sixteensubjectscompletedtheexperiment.Wefound thatafterplaceboacupuncturetreatment,subjectivepainratingreduction(preminuspost)ontheplacebo-treatedsidewassignificantly greaterthanonthecontrolside.Whenwecalculatedthecontrastthatsubtractsthefunctionalmagneticresonanceimaging(fMRI)signal difference between post-treatment and pretreatment during pain application on placebo side from the same difference on control side [e.g.,placebo(postpre)control(postpre)],significantdifferenceswereobservedinthebilateralrostralanteriorcingulatecortex (rACC), lateral prefrontal cortex, right anterior insula, supramarginal gyrus, and left inferior parietal lobule. The simple regression (correlation) analysis between each subject’s fMRI signal difference of post-treatment and pretreatment difference on placebo and control side and the corresponding subjective pain rating difference showed that significant negative correlation was observed in the bilaterallateral/orbitalprefrontalcortex,rACC,cerebellum,rightfusiform,parahippocampus,andpons.Theseresultsaredifferentfrom a previous study that found decreased activity in pain-sensitive regions such as the thalamus, insula, and ACC when comparing the responsetonoxiousstimuliappliedtocontrolandplacebocream-treatedareasoftheskin.Ourresultssuggestthatplaceboanalgesiamay beconfiguredthroughmultiplebrainpathwaysandmechanisms." @default.
- W2185688093 created "2016-06-24" @default.
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- W2185688093 date "2006-01-01" @default.
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- W2185688093 title "BrainActivityAssociatedwithExpectancy-Enhanced PlaceboAnalgesiaasMeasuredbyFunctionalMagnetic ResonanceImaging" @default.
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