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- W2185698336 abstract "In this study, stability-indicating methods for the determination of cefepime hydrochloride (CPM) were conducted by the application of spectrophotometry, chemometry and high-performance liquid chromatography (HPLC). Five different, accurate, sensitive and reproducible methods were applied for the simultaneous analysis of cefepime hydrochloride (CPM) in the presence of its acid and alkaline degradation products in their laboratory prepared mixtures and pharmaceutical preparations. The first method is based on derivative spectrophotometry. First derivative spectrophotometry was applied where CPM was determined at 279 and 312 nm in the presence of its alkaline degradation product and also second derivative spectrophotometry was applied where CPM was determined at 236 nm in the presence of its acid degradation product. The second method is based on the first derivative of ratio spectrophotometry ( 1 DD) of CPM at 258 and 286 nm in the presence of its acid degradation product and at 251 and 285 nm in the presence of its alkaline degradation product. The third method is based on ratio subtraction spectrophotometry where the drug is determined at 236 nm in laboratory prepared mixtures of CPM with its acid or alkaline degradation product. The fourth method is the application of multivariate calibration models, namely, Principle Component Regression (PCR) and Partial Least Squares (PLS). The four proposed spectrophotometric methods permit the determination of CPM in the range of 3.0-30.0 μg/ml. The fifth method is an isocratic reversed-phase HPLC procedure, a Zorbax C18 column was used to separate CPM from its acid and alkaline degradation products using acetonitrile: water (20:80, v/v) as a mobile phase and detection at 254 nm. The suggested procedures were successfully applied for the analysis of CPM in bulk powder and in pharmaceutical preparations. The results obtained by the proposed methods were statistically comparable with those obtained by the official method. All the proposed methods were validated according to the International Conference on Harmonization (ICH) guidelines." @default.
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- W2185698336 date "2013-01-01" @default.
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- W2185698336 title "Original Article Development and Validation of Spectrophotometric, Chemometric and High Pressure Liquid Chromatographic Methods for the Determination of Cefepime Hydrochloride In The Presence of Its Acid and Alkaline Degradation Products" @default.
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