Matches in SemOpenAlex for { <https://semopenalex.org/work/W2185706103> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2185706103 endingPage "7" @default.
- W2185706103 startingPage "22" @default.
- W2185706103 abstract "Acitretin, a beneficial retinoid, was shown to undergo constant structural interconversions among its geometrical isomers (all-trans-acitretin, 9-cis-acitretin, 13-cis-acitretin, 9, 13-di-cis-acitretin, etc.) by photoisomerization under natural light. The photoisomerization was zero order reaction with an apparent velocity of 4x107 M/min under illumination by white fluorescent lamps (1, 200 lx). An equilibrium mixture of the geometrical isomers (all-trans-acitretin 20%, 9-cis-acitretin 15%, 13-cis-acitretin 30%, 9, 13-di-cis-acitretin 15%, and unidentified compounds 20%) was formed at around 30 min. Equilibrium mixtures with similar composition were obtained by photoisomerization reactions starting from other geometrical isomers. Geometrical isomers of acitretin thus formed, showed different effects to induce differentiation of human acute promyelocytic leukemia cells (HL-60 cells): activity of all-trans-acitretin (ED50, 3.2 x 10(-6) M), 9-cis-acitretin (ED50, 2.3 x 10(-5)M), 13-cis-acitretin (ED50, 1.1 x 10(-5)M), 9, 13-di-cis-acitretin (ED50, 2.6 x 10(-6)M). 9-cis-Acitretin acted synergistically with all-trans-acitretin, 13-cis-acitretin and 9, 13-di-cis-acitretin on HL-60 cells. On the other side, all-trans-acitretin, 13-cis-acitretin and 9, 13-di-cis-acitretin acted additively. Geometrical isomers of acitretin showed different effects on differentiation of human epidermal keratinocytes; expression of keratinocyte differentiation markers, keratin 1 and keratin 10, were suppressed more strongly by 9-cis-acitretin and 13-cis-acitretin as compared to all-trans-acitretin or 9, 13-di-cis-acitretin." @default.
- W2185706103 created "2016-06-24" @default.
- W2185706103 creator A5010075867 @default.
- W2185706103 creator A5037866266 @default.
- W2185706103 creator A5055028868 @default.
- W2185706103 creator A5083879113 @default.
- W2185706103 date "2002-02-01" @default.
- W2185706103 modified "2023-09-27" @default.
- W2185706103 title "Constant variation in structure and function of geometrical isomers of acitretin under natural light." @default.
- W2185706103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22896885" @default.
- W2185706103 hasPublicationYear "2002" @default.
- W2185706103 type Work @default.
- W2185706103 sameAs 2185706103 @default.
- W2185706103 citedByCount "0" @default.
- W2185706103 crossrefType "journal-article" @default.
- W2185706103 hasAuthorship W2185706103A5010075867 @default.
- W2185706103 hasAuthorship W2185706103A5037866266 @default.
- W2185706103 hasAuthorship W2185706103A5055028868 @default.
- W2185706103 hasAuthorship W2185706103A5083879113 @default.
- W2185706103 hasConcept C104317684 @default.
- W2185706103 hasConcept C126661725 @default.
- W2185706103 hasConcept C16005928 @default.
- W2185706103 hasConcept C161790260 @default.
- W2185706103 hasConcept C176788430 @default.
- W2185706103 hasConcept C178790620 @default.
- W2185706103 hasConcept C185592680 @default.
- W2185706103 hasConcept C2775954498 @default.
- W2185706103 hasConcept C2778496887 @default.
- W2185706103 hasConcept C2780564577 @default.
- W2185706103 hasConcept C2781121885 @default.
- W2185706103 hasConcept C55493867 @default.
- W2185706103 hasConcept C71240020 @default.
- W2185706103 hasConcept C71924100 @default.
- W2185706103 hasConcept C85311670 @default.
- W2185706103 hasConceptScore W2185706103C104317684 @default.
- W2185706103 hasConceptScore W2185706103C126661725 @default.
- W2185706103 hasConceptScore W2185706103C16005928 @default.
- W2185706103 hasConceptScore W2185706103C161790260 @default.
- W2185706103 hasConceptScore W2185706103C176788430 @default.
- W2185706103 hasConceptScore W2185706103C178790620 @default.
- W2185706103 hasConceptScore W2185706103C185592680 @default.
- W2185706103 hasConceptScore W2185706103C2775954498 @default.
- W2185706103 hasConceptScore W2185706103C2778496887 @default.
- W2185706103 hasConceptScore W2185706103C2780564577 @default.
- W2185706103 hasConceptScore W2185706103C2781121885 @default.
- W2185706103 hasConceptScore W2185706103C55493867 @default.
- W2185706103 hasConceptScore W2185706103C71240020 @default.
- W2185706103 hasConceptScore W2185706103C71924100 @default.
- W2185706103 hasConceptScore W2185706103C85311670 @default.
- W2185706103 hasIssue "1" @default.
- W2185706103 hasLocation W21857061031 @default.
- W2185706103 hasOpenAccess W2185706103 @default.
- W2185706103 hasPrimaryLocation W21857061031 @default.
- W2185706103 hasRelatedWork W1971981307 @default.
- W2185706103 hasRelatedWork W2066994501 @default.
- W2185706103 hasRelatedWork W2140865108 @default.
- W2185706103 hasRelatedWork W2170503291 @default.
- W2185706103 hasRelatedWork W2185706103 @default.
- W2185706103 hasRelatedWork W2324273242 @default.
- W2185706103 hasRelatedWork W2951844516 @default.
- W2185706103 hasRelatedWork W2952586250 @default.
- W2185706103 hasRelatedWork W3004619871 @default.
- W2185706103 hasRelatedWork W3005085313 @default.
- W2185706103 hasVolume "39" @default.
- W2185706103 isParatext "false" @default.
- W2185706103 isRetracted "false" @default.
- W2185706103 magId "2185706103" @default.
- W2185706103 workType "article" @default.