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• W2185720454 endingPage "R1338" @default.
• W2185720454 startingPage "R1334" @default.
• W2185720454 abstract "Various growth factors are involved in sleep regulation. Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family; it and its receptors are found in normal brain. Furthermore, cerebral cortical levels of BDNF mRNA have a diurnal variation and increase after sleep deprivation. Therefore, we investigated whether BDNF would promote sleep. Twenty-four male Sprague-Dawley rats (320–380 g) and 25 male New Zealand White rabbits (4.5–5.5 kg) were surgically implanted with electroencephalographic (EEG) electrodes, a brain thermistor, and a lateral intracerebroventricular cannula. The animals were injected intracerebroventricularly with pyrogen-free saline and, on a separate day, one of the following doses of BDNF: 25 or 250 ng in rabbits; 10, 50, or 250 ng in rats. The EEG, brain temperature, and motor activity were recorded for 23 h after the intracerebroventricular injections. BDNF increased time spent in non-rapid eye movement sleep (NREMS) in rats and rabbits and REMS in rabbits. Current results provide further evidence that various growth factors are involved in sleep regulation." @default.
• W2185720454 created "2016-06-24" @default.
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• W2185720454 date "1999-05-01" @default.
• W2185720454 modified "2023-10-16" @default.
• W2185720454 title "Brain-derived neurotrophic factor enhances spontaneous sleep in rats and rabbits" @default.
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• W2185720454 doi "https://doi.org/10.1152/ajpregu.1999.276.5.r1334" @default.
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