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- W2185746840 abstract "Background/Aim. Peri-implantitis presents inflammatory process that affects soft and hard supporting tissues of os- seointegrated implant based on inflammatory osteoclasto- genesis. The aim of this study was to investigate whether re- ceptor activator of nuclear factor kappa B (RANK) con- centrations in peri-implant crevicular fluid could be associ- ated with clinical parameters that reflect inflammatory na- ture of peri-implantitis. Methods. The study included 67 patients, 22 with diagnosed peri-implantitis, 22 persons with healthy peri-implant tissues and 23 patients with periodon- titis. Clinical parameters from each patient were recorded and samples of peri-implant/gingival crevicular fluid were collected for the enzyme-linked immunosorbent assay (ELISA) analysis. Results. RANK concentration was sig- nificantly increased in samples from the patients with peri- implantitis when compared to healthy implants (p < 0.0001), where the average levels were 9 times higher. At the same time RANK concentration was significantly higher in peri- implantitis than in periodontitis sites (p < 0.0001). In im- plant patients pocket depths and bleeding on probing values were positively associated with high RANK concentrations (p < 0.0001). Conclusion. These results revealed associa- tion of increased RANK concentration in samples of peri- implant/gingival crevicular fluid with peri-implant inflam- mation and suggests that RANK could be a pathologic de- terminant of peri-implantitis, thereby a potential parameter in assessment of peri-implant tissue inflammation and a potential target in designing treatment strategies." @default.
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- W2185746840 date "2013-01-01" @default.
- W2185746840 modified "2023-09-24" @default.
- W2185746840 title "Receptor Activator of Nuclear Factor Kappa B (RANK) as a determinant of peri-implantitis Receptor aktivatora nuklearnog faktora kapa B kao činioc periimplantitisa" @default.
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