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- W2185760131 abstract "The aim of this study was to evaluate pre- operative tumour expression of NAD(P)H:quinone oxidoreductase 1 (NQO1) along with other biological markers as potential predictors of pathological com- plete response (pCR) to neoadjuvant docetaxel, dox- orubicin, and cyclophosphamide-containing (TAC) chemotherapy in patients with primary breast can- cer. Sixty-one patients who received neoadjuvant chemotherapy (NCT) with TAC regimen were en- rolled in this prospective study. The pre- and post- NCT expression of oestrogen receptor (ER), proges- terone receptor (PR), epidermal growth factor receptor 1 and 2 (EGFR and HER2), NQO1, Ki-67 proliferation index, multidrug resistance protein 1 (MDR1), p53 and BCL2 were evaluated by immuno- histochemistry. The pCR was reached in 14 patients (23 % of the study group). Multivariate analysis demonstrated that patients with ER-, PR-, NQO1- negative, and Ki‑67‑positive tumours had a signifi- cantly higher chance to achieve pCR. Within the bio- logical subtypes, the highest pCR rate (50 %) was seen in triple-negative (i.e. ER-, PR-, HER2-) tu- mours. Post-operative evaluation showed that in comparison to pre-operative tissue samples, NQO1 expression was significantly increased, while Ki‑67 and HER2 decreased, in the residual tissue after NCT. In conclusion, the present data suggests that NQO1 expression may be a novel diagnostic bio- marker for the prediction of positive response to NCT in patients with breast cancer." @default.
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- W2185760131 date "2012-01-01" @default.
- W2185760131 modified "2023-09-27" @default.
- W2185760131 title "Low Expression of NQO1 Predicts Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Patients Treated with TAC Regimen (breastcancer/neoadjuvanttherapy/predictivebiomarkers)" @default.
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