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• W2185794323 abstract "Procaine, trimecaine and tetracaine inhibit the active transport of norepinephrine and choline in rat brain synaptosomes with half maximal effects at lCr4-6.10~5 mol/1. Depolarization with veratrine (0.1 mg/ml) or 50 mmol/'l KC1 resulted in neurotransmit ter release. Tetrodotoxin (5.10 7 mol/1) or charged tertiary amines (10~4 mol/1) prevented the veratrine effect but not that of KC1. Microviscosity of synaptic membrane lipid bilayer, evaluated by mobilities of doxylstearate spin labels, was decreased at tetracaine concentrations exceeding 103 mol/1. It is suggested that the uptake systems for neurotransmitters and sodium channels are blocked through direct action of anesthetics or owing to changes in the annular lipids." @default.
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• W2185794323 date "1982-01-01" @default.
• W2185794323 modified "2023-09-26" @default.
• W2185794323 title "Blockade of Sodium Channels and Transmitter Uptake Systems in Synaptosomes by Local Anesthetics: Lipid-Mediated or Direct Influence?" @default.
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