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- W2185804565 abstract "The complex genetic susceptibility for breast cancer includes highly penetrating and low- penetrating genetic markers. eNOS (7q36), ACE (17q23) and AGTR1 (3q24) are candidate loci for breast cancer. The aim of this study was to test the potential association of eNOS 4ab, ACE ID, AGTR1 A1166T polymorphisms and Torque teno virus (TTV) infections with sporadic breast cancer in Romania. For this case-control study were selected women with sporadic breast cancer (n=100) and healthy women (n=100). The eNOS 4ab, ACE ID, AGTR1 A1166T polymorphisms and presence of TTV DNA were assessed by PCR-based protocols. The polymorphisms' distribution was in accordance with Hardy-Weinberg equilibrium. No significant association with breast cancer was found for investigated polymorphisms considered individually or in combinations of two or three markers (p>0.05). TTV infections were more frequent in cancer patients than in control (84% vs. 60%, p=0.00016). A preferential distribution of TTV in patients with sporadic breast cancer, especially in those carrying eNOS bb genotype (OR=4.88, 95%CI: 2.01- 11.9, p=0.00025) or ACE I variant (OR=4.07, 95%CI: 1.85- 8.97, p=0.0003), was observed. This study revealed a preferential distribution of TTV infections in women with sporadic breast cancer, carriers of eNOS bb genotype or ACE I variant." @default.
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- W2185804565 date "2013-01-01" @default.
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- W2185804565 title "Potential implication of genetic polymorphisms and Torque teno virus in sporadic breast cancer" @default.
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