FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2185824428> ?p ?o ?g. }

• W2185824428 abstract "Chlorambucil, (4-(4-(Bis (2-chloroethyl) amino) phenyl) butanoic acid), is a well-established bifunctional alkylating agent indicated in chronic leukemia. Kolaviron (KV), a biflavonoid from Garcinia kola and L-ascorbic acid (ASA) are known to offer protection against oxidative damage in vivo. This study was designed to investigate the protective role of KV and ASA on chlorambucil (CLB)-induced toxicity in rat. Twenty male Wistar rats (180-200g) were randomized into four groups. Group-I animals served as control, Group-II received chlorambucil (0.2mg/kg b.w. p.o.), Group III (0.2mg/kg chlorambucil and 100mg/kg kolaviron p.o.), and Group IV (0.2mg/kg chlorambucil and 100mg/kg L-ascorbic acid p.o.) respectively for 14 days. Chlorambucil induced marked renal and liver damage as evident by a significant increase in plasma bilirubin, urea, and creatinine by 233%, 74% and 174% respectively (p˂0.05). Similarly, plasma ALP, ALT, and AST rose significantly by 103%, 43%, and 59% respectively (p˂0.05). However, co-treatment with KV and ASA caused reduction in the levels of urea, creatinine, bilirubin, ALP, ALT, and AST relative to chlorambucil rats. Also, hepatic malondialdehyde content of chlorambucil-treated rats increased significantly by 113% (p˂0.05). However, co-treatment with KV and ASA significantly attenuated chlorambucil-induced alteration in hepatic lipid peroxidation. Moreover, chlorambucil treatment caused a marked depletion in antioxidant status as hepatic vitamin C, GSH, GST, SOD and catalase activities by were significantly reduced 33%, 39%, 48.2%, 47.2%; and 55.8% respectively (p˂0.05). Co-treatment with KV and ASA however, significantly ameliorated the chlorambucil-induced reduction in vitamin C, GSH, GST, SOD and catalase levels. Overall, kolaviron and L-ascorbic acid protected against chlorambucil-induced damages in the liver and kidney of the rat." @default.
• W2185824428 created "2016-06-24" @default.
• W2185824428 creator A5020089692 @default.
• W2185824428 creator A5077430779 @default.
• W2185824428 date "2014-01-01" @default.
• W2185824428 modified "2023-09-27" @default.
• W2185824428 title "ISSN 2249-9709 Original Article Kolaviron and L-Ascorbic acid Ameliorates Chlorambucil -Induced Hepatic and Renal Toxicity in Rat" @default.
• W2185824428 cites W149583333 @default.
• W2185824428 cites W1506043065 @default.
• W2185824428 cites W1531502404 @default.
• W2185824428 cites W1536070045 @default.
• W2185824428 cites W154375584 @default.
• W2185824428 cites W1581414347 @default.
• W2185824428 cites W1599134993 @default.
• W2185824428 cites W1750690213 @default.
• W2185824428 cites W1768247331 @default.
• W2185824428 cites W1801614968 @default.
• W2185824428 cites W1967234838 @default.
• W2185824428 cites W1967620965 @default.
• W2185824428 cites W1968967017 @default.
• W2185824428 cites W1971126613 @default.
• W2185824428 cites W1974788436 @default.
• W2185824428 cites W1976622405 @default.
• W2185824428 cites W1984604518 @default.
• W2185824428 cites W1985363254 @default.
• W2185824428 cites W1986798142 @default.
• W2185824428 cites W1987553815 @default.
• W2185824428 cites W1987739207 @default.
• W2185824428 cites W1993481682 @default.
• W2185824428 cites W1998926818 @default.
• W2185824428 cites W2001330114 @default.
• W2185824428 cites W2006260980 @default.
• W2185824428 cites W2010281379 @default.
• W2185824428 cites W2011869432 @default.
• W2185824428 cites W2016591171 @default.
• W2185824428 cites W2024749059 @default.
• W2185824428 cites W2026684949 @default.
• W2185824428 cites W2027213706 @default.
• W2185824428 cites W2027257361 @default.
• W2185824428 cites W2027444046 @default.
• W2185824428 cites W2032389814 @default.
• W2185824428 cites W2034435394 @default.
• W2185824428 cites W2040345263 @default.
• W2185824428 cites W2041504874 @default.
• W2185824428 cites W2046060026 @default.
• W2185824428 cites W2051867810 @default.
• W2185824428 cites W2052528461 @default.
• W2185824428 cites W2060035882 @default.
• W2185824428 cites W2062331203 @default.
• W2185824428 cites W2062512366 @default.
• W2185824428 cites W2063483499 @default.
• W2185824428 cites W2065740620 @default.
• W2185824428 cites W2066002266 @default.
• W2185824428 cites W2073092594 @default.
• W2185824428 cites W2080788266 @default.
• W2185824428 cites W2086042291 @default.
• W2185824428 cites W2088619566 @default.
• W2185824428 cites W2094830334 @default.
• W2185824428 cites W2095561300 @default.
• W2185824428 cites W2100757193 @default.
• W2185824428 cites W2103478791 @default.
• W2185824428 cites W2111088278 @default.
• W2185824428 cites W2114753349 @default.
• W2185824428 cites W2115692333 @default.
• W2185824428 cites W2126447365 @default.
• W2185824428 cites W2132878122 @default.
• W2185824428 cites W2135347204 @default.
• W2185824428 cites W2148034160 @default.
• W2185824428 cites W2151831386 @default.
• W2185824428 cites W2157365317 @default.
• W2185824428 cites W2160328272 @default.
• W2185824428 cites W2165201727 @default.
• W2185824428 cites W2186446007 @default.
• W2185824428 cites W2317557661 @default.
• W2185824428 cites W240678930 @default.
• W2185824428 cites W2473367646 @default.
• W2185824428 cites W2619514252 @default.
• W2185824428 cites W286304560 @default.
• W2185824428 cites W38682668 @default.
• W2185824428 cites W4884274 @default.
• W2185824428 hasPublicationYear "2014" @default.
• W2185824428 type Work @default.
• W2185824428 sameAs 2185824428 @default.
• W2185824428 citedByCount "0" @default.
• W2185824428 crossrefType "journal-article" @default.
• W2185824428 hasAuthorship W2185824428A5020089692 @default.
• W2185824428 hasAuthorship W2185824428A5077430779 @default.
• W2185824428 hasConcept C126322002 @default.
• W2185824428 hasConcept C134018914 @default.
• W2185824428 hasConcept C181199279 @default.
• W2185824428 hasConcept C185592680 @default.
• W2185824428 hasConcept C2776694085 @default.
• W2185824428 hasConcept C2776755627 @default.
• W2185824428 hasConcept C2777513400 @default.
• W2185824428 hasConcept C2777866208 @default.
• W2185824428 hasConcept C2780306776 @default.
• W2185824428 hasConcept C29730261 @default.
• W2185824428 hasConcept C2986274086 @default.
• W2185824428 hasConcept C31903555 @default.
• W2185824428 hasConcept C538909803 @default.

• next