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- W2185856184 abstract "The clinical significance of donor specific HLA antibody (DSA), in solid organ transplantation, is still debated. While it is well known that hyperacute antibody-mediated rejection (AMR) may occur in the presence of pre-transplant DSA, the presence of post-transplant de-novo DSA not always causes AMR. We discuss the role of DSA in solid organ transplantation, the methodology to detect DSA and the effect of immunosuppressive therapy on DSA production. 2004 Terasaki and Ozawa suggested monitoring of anti-HLA antibodies as predictive of transplantation outcome showing that the presence of post- transplant anti-HLA antibodies were at higher risk for acute and chronic AMR, compared with those without antibodies (p=0.00003) (5). Very recently a new definition of acute rejection has introduced the concept that appearance of DSA is critical together with the presence of c4d positive peritubular cells and creatinine increase, to make the diagnosis of acute antibody mediated rejection (AAMR)." @default.
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- W2185856184 date "2013-01-01" @default.
- W2185856184 modified "2023-09-27" @default.
- W2185856184 title "Donor-Specific Antibody in Solid Organ Transplantation: Where are We?" @default.
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