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- W2185879783 abstract "A series of Quinazoline -4-(3H) ones were synthesized and characterized by IR, 1 H NMR and mass spectral Analysis. In the present paper, The Invitro Anti-inflammatory activity of synthesized compounds were studied using denaturation of protein by Bovine serum albumin (BSA) and results were compared with std Ibuprofen. 3-(4Bromo phenyl)-4-(3H)quinazolinone , 3-(4-methyl phenyl)-4-(3H)quinazolinone exhibited highest invitro antiinflammatory activity among the synthesized compounds .The antioxidant capacity of Quinazolinones were studied using different Invitro analytical methodologies such as 1,1 diphenyl -2-picryl-hydrazyl free radical ( DPPH ) scavenging , total reducing ability determination using Fe 3+ , Fe 2+ transformation method , Nitric oxide scavenging & hydrogen peroxide scavenging , were used as the reference antioxidant radical scavenger compounds.3-(4Bromophenyl)-4-(3H)quinazolinone,3-(4-methoxyphenyl)-4-(3H)quinazolinone,3-(4-methyl phenyl)-4(3H)quinazolinone, and 3-(2,6dimethylphenyl)-4-(3H)quinazolinone exhibited highest scavenger activity among the synthesized compounds , in addition, methylated compound exhibited better activity among the synthesized compound." @default.
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- W2185879783 date "2011-01-01" @default.
- W2185879783 modified "2023-09-27" @default.
- W2185879783 title "INVITRO STUDY OF ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF 4-(3H) - QUINAZOLINONE DERIVATIVES" @default.
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