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- W2185940970 abstract "Regulation of gene activity is a multi-factorial procedure that requires coordination of complex regulatory network. MicroRNA is a novel gene regulator that requires exposition of open questions concerning selection of targets and mechanisms. MicroRNA target prediction using bioinformatics tool is often the first line of approaching the multifarious system of gene regulation. Such methodologies will helps in setting search priorities for experimental validation of gene controlling mechanisms. But finding a functional miRNA target is still a challenging task. In the present study we focused on gene regulation potentiality of miRNAs to investigate their target sites within GJB2 (a candidate gene for hearing impairment that codes for connexion 26). Mapping was made for miRNAs to establish collaborative regulatory profiles. This computational setting will subsequently allow better in vitro confirmation of the regulatory networks in cellular systems and possibly later on in transgenic animal models for this severe human anomaly of hearing loss. It is thus concluded that this is the first pilot approach to investigate predicted miRNA involved in GJB2 gene regulation." @default.
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- W2185940970 date "2014-03-28" @default.
- W2185940970 modified "2023-09-26" @default.
- W2185940970 title "In silico MicroRNAs target identification within the GJB2 Gene" @default.
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- W2185940970 doi "https://doi.org/10.12692/ijb/4.7.38-49" @default.
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